Nicotine EP Impurity G CAS 494-52-0
| CAS No. | 494-52-0 |
| Molecular Formula | C10H14N2 |
| Molecular Weight | 162.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Nicotine EP Impurity G (CAS 494-52-0), a pharmacopoeial impurity reference standard (molecular formula C10H14N2, MW 162.23 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Nicotine EP Impurity G (C10H14N2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 162.23 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Nicotine EP Impurity G meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H14N2 |
| Molecular Weight | 162.23 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 2 |
Related Nicotine Standards
Recommended Standards
- Latanoprost Impurity 12 (CAS 125637-06-1)
- Amifostine Impurity 10 (CAS 10563-27-6)
- Eperisone Impurity 14 (CAS 191543-16-5)
- Mianserin Impurity 72 (CAS CATO-C4X-136972)
- Dexmedetomidine Impurity 86 (CAS CATO-C4X-123086)
- Gentamicin Impurity 12 (CAS 25876-11-3)
- Levofloxacin Impurity 31 (CAS CATO-C4X-137131)
- 4-Chloro-5-phenyl-1,2,3-dithiazol-1-ium chloride (CAS 880494-73-5)
- 2-Nitro-3-(trifluoromethoxy)benzyl alcohol (CAS 1258547-43-1)
- ethyl 2-cyclopropyl-4-oxo-1,4-dihydropyrimidine-5-carboxylate hydrochloride (CAS 1797949-27-9)
- (E)-3-(4-chloro-2-(methylsulfonyl)phenyl)acrylic acid (CAS 849035-82-1)
- 1-(5-chloro-8-(pyridin-3-ylamino)isoquinolin-3-yl)-3-ethylurea (CAS 1338254-55-9)
- 3-(2-Chloroacetamido)-N-(3-(trifluoromethyl)phenyl)benzamide (CAS 565171-06-4)
- Insulin Degludec Impurity 8 (CAS CATO-C4X-21578)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com