Nicotine Impurity C34 CAS 525-74-6
| CAS No. | 525-74-6 |
| Molecular Formula | C10H12N2 |
| Molecular Weight | 160.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO supplies Nicotine Impurity C34 (CAS 525-74-6), a pharmacopoeial impurity reference standard (molecular formula C10H12N2, MW 160.22 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Nicotine Impurity C34 (C10H12N2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), Nicotine Impurity C34 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H12N2 |
| Molecular Weight | 160.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 2 |
Related Nicotine Standards
Recommended Standards
- N-ethyl-2-methylbenzimidazole (CAS 5805-76-5)
- 2700-22-3 Malononitrile, benzylidene- Propanedinitrile, (phenylmethylene)- (9CI) beta,beta-Styrenedicarbonitrile F 2370 AI3-19689 Benzal-malonitril [German] Benzalmalononitrile Benzylidene malononitrile Benzylidenemalonodinitrile Benzylidenemalononitrile BMN alpha-Cyanocinnamonitrile 2,2-Dicyano-1-phenylethylene beta,beta-Dicyanostyrene EINECS 220-283-6 NSC 490 2-Phenyl-1,1-dicyanoethylene TL 237 Benzal-malonitril (CAS 2700-22-3)
- N-Ethyl-1H-indol-4-amine (CAS 908264-71-1)
- (1H-indol-3-yl)-N-methylmethanamine (indol-3-yl)-N-methylmethanamine 1-(1H-indol-3-yl)-N-methylmethanamine 3-(methylaminomethyl)indole 36284-95-4 CHEBI:137310 N-methyl-3-aminomethylindole N-methyl-N-(indol-3-ylmethyl)amine N-norgramine NMAMI (CAS 36284-95-4)
- Irbesartan impurity 37 (CAS 1415462-83-7)
- Acotiamide Impurity 35 (CAS CATO-C4X-111435)
- Xanomeline impurity 53 (CAS CATO-C4X-330153)
- (6-(Cyanomethyl)pyridin-3-yl)boronic acid (CAS 1451154-45-2)
- 2’-Amino-5’-bromo-4’-methylacetophenone (CAS 817209-21-5)
- 2-(((1-Benzylpiperidin-2-yl)methyl)(methyl)amino)ethanol (CAS 1353974-32-9)
- N-(cyclohexylmethyl)-O-methylhydroxylamine (CAS 1549665-47-5)
- 4-Methoxy-2-(methylthio)-6-(trifluoromethyl)pyrimidine-5-carboxylic acid (CAS 1186404-89-6)
- 3-((3,4-Dimethylphenyl)sulfonyl)-7-hydroxy-2H-chromen-2-one (CAS 866013-26-5)
- Semaglutide Impurity 157 (x TFA Salt) (CAS CATO-C4X-2226157)
Why CATO?
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