Estradiol Benzoate EP Impurity H CAS 4954-17-0
| CAS No. | 4954-17-0 |
| Molecular Formula | C27H30O4 |
| Molecular Weight | 418.52 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Estradiol Benzoate EP Impurity H (C27H30O4) contains a steroid core, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 13.0, corresponding to approximately 13 ring(s) or double-bond equivalent(s). With a molecular weight of 418.52 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
CATO supplies Estradiol Benzoate EP Impurity H (CAS 4954-17-0), a pharmacopoeial impurity reference standard (molecular formula C27H30O4, MW 418.52 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C27H30O4 |
| Molecular Weight | 418.52 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
Related Estradiol Standards
- Estradiol-3,17b-dibutyrate (CAS 63042-23-9)
- Estradiol Impurity 39 (CAS 50394-95-1)
- Estradiol Impurity 31 (CAS CATO-C4X-163631)
- Estradiol Impurity 49 (CAS CATO-C4X-163649)
- Estradiol Impurity 46 (CAS CATO-C4X-163646)
- Estradiol Impurity 32 (CAS CATO-C4X-163632)
- Estradiol Impurity 53 (CAS CATO-C4X-163653)
- Estradiol Impurity 43 (CAS 19590-55-7)
Recommended Standards
- 3′-thymidylic acid, 5′-(dihydrogen phosphate) (CAS 2863-04-9)
- Hellebrigenol (CAS 508-79-2)
- 11β,17,21-Trihydroxy-16α-methyl-pregn-4-ene-3,20-dione 21-Acetate (CAS 41020-56-8)
- Hydrocortisone 17-Propionate (CAS 65980-97-4)
- Ebastine Impurity 9 (CAS 632-50-8)
- Tofacitinib Impurity 160 (CAS CATO-C4X-1079160)
- Trelagliptin Impurity 42 (CAS CATO-C4X-104642)
- 2-Amino-4,5,6,7-tetrahydro-6-phenylbenzothiazole 79932-21-1 9909AE C13H14N2S (CAS 79932-21-1)
- [cis-5-phenyloxolan-2-yl]methanamine hydrochloride (CAS 1808640-98-3)
- Allithiamine (CAS 554-44-9)
- N-(4-methoxyphenyl)-3-(thiophen-2-yl)-6-(trifluoromethyl)thieno[3,2-b]pyridine-2-carboxamide (CAS 477845-18-4)
- 6-Chloro-4-methyl-N-(2-morpholinoethyl)benzo[d]thiazol-2-amine (CAS 1206992-81-5)
- (8-Amino-1,4-dioxaspiro[4.5]Decan-8-yl)methanol (CAS 1607592-18-6)
- Semaglutide impurity 88 (CAS CATO-C4X-222688)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com