(2-(4-Chloro-2-methylphenoxy)pyridin-3-yl)(4-(2-fluorophenyl)piperazin-1-yl)methanone CAS 497060-65-8
| CAS No. | 497060-65-8 |
| Molecular Formula | C23H21ClFN3O2 |
| Molecular Weight | 425.88 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of (2-(4-Chloro-2-methylphenoxy)pyridin-3-yl)(4-(2-fluorophenyl)piperazin-1-yl)methanone is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
(2-(4-Chloro-2-methylphenoxy)pyridin-3-yl)(4-(2-fluorophenyl)piperazin-1-yl)methanone (CAS 497060-65-8) is a high-purity analytical reference standard with the molecular formula C23H21ClFN3O2 and a molecular weight of 425.88 g/mol.
The molecular framework of (2-(4-Chloro-2-methylphenoxy)pyridin-3-yl)(4-(2-fluorophenyl)piperazin-1-yl)methanone (C23H21ClFN3O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (2-(4-Chloro-2-methylphenoxy)pyridin-3-yl)(4-(2-fluorophenyl)piperazin-1-yl)methanone meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H21ClFN3O2 |
| Molecular Weight | 425.88 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 1-(3-Chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-(pyridin-2-ylmethyl)methanesulfonamide (CAS 1001917-35-6)
- N-(3-Chloro-4-methoxyphenyl)-2-{4-oxo-7-phenyl-3H,4H-thieno[3,2-d]pyrimidin-3-yl}acetamide (CAS 1105235-07-1)
- N-(4-chloro-2-methylphenyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide (CAS 477872-23-4)
- 1-(4-Chloro-2-methylphenyl)-3-(1-((4-fluorophenyl)sulfonyl)piperidin-4-yl)urea (CAS 672950-46-8)
- 2-((3-Chloro-4-fluorophenyl)amino)-N-(4-(piperidin-1-ylsulfonyl)phenyl)acetamide (CAS 853695-44-0)
- 4-Chloro-N'-(1-(3-fluorobenzyl)piperidine-4-carbonyl)benzenesulfonohydrazide (CAS 478259-18-6)
- Ethyl 1-(2-(3-(3-chloro-4-methoxyphenyl)ureido)-2-methylpropanoyl)piperidine-4-carboxylate (CAS 1439375-03-7)
- 1775431-22-5 2-(3-chloro-4-methoxyphenyl)-1-{4-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]piperidin-1-yl}ethan-1-one BS-8217 (CAS 1775431-22-5)
Recommended Standards
- Cts-1027 (CAS 193022-04-7)
- 4-Formyl-2-methoxyphenyl 2-chloro-5-(diethylsulfamoyl)benzoate (CAS 380427-16-7)
- N1-(3-(2-Chlorophenyl)-5-methyl-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidin-7-yl)-N2,N2-diethylethane-1,2-diamine (CAS 1015598-30-7)
- Ls2265 (CAS 72678-30-9)
- 2-(((2,3-Dihydro-1H-inden-5-yl)amino)methyl)-6-methoxyphenol (CAS 1019608-80-0)
- 4-Hydroxy-1-(thiophen-2-ylsulfonyl)pyrrolidine-2-carboxylic acid (CAS 251310-43-7)
- tert-Butyl (3-methoxy-2-nitrophenyl)carbamate (CAS 158461-29-1)
- 1-(2-Methylpiperazin-1-yl)nonan-1-one (CAS 1240577-57-4)
- Ethyl 7-chloro-6-methoxy-4-(methylamino)quinoline-3-carboxylate (CAS 1315351-69-9)
- rel-(3aR,5r,6aS)-Octahydrocyclopenta[c]pyrrol-5-ol (CAS 1256333-43-3)
- [[2-(4-Hydroxypiperidin-1-yl)-2-oxoethyl]-(4-methoxyphenyl)amino]acetic acid (CAS 1142205-76-2)
- 3-((8-Methylimidazo[1,2-a]pyridin-2-yl)methoxy)benzoic acid (CAS 929975-03-1)
- 2-[4-(trifluoromethyl)pyridin-2-yl]ethan-1-amine (CAS 1060805-59-5)
- TRAF6 Control Peptide trifluoroacetate salt (CAS 852690-80-3)
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