5-Chloro-4-{4-methyl-2-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}pyrimidin-2-amine CAS 499795-98-1
| CAS No. | 499795-98-1 |
| Molecular Formula | C15H10ClF3N4S |
| Molecular Weight | 370.78 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-Chloro-4-{4-methyl-2-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}pyrimidin-2-amine.
CATO supplies 5-Chloro-4-{4-methyl-2-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}pyrimidin-2-amine (CAS 499795-98-1), a certified reference material (molecular formula C15H10ClF3N4S, MW 370.78 g/mol) for analytical method development and quality control.
The molecular framework of 5-Chloro-4-{4-methyl-2-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}pyrimidin-2-amine (C15H10ClF3N4S) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H10ClF3N4S |
| Molecular Weight | 370.78 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Chloro Standards
- (2E)-7-Chloro-2-({[2-(trifluoromethyl)phenyl]amino}methylidene)-3,4-dihydro-2H-1,4-benzothiazin-3-one (CAS 338417-10-0)
- (2E)-7-Chloro-2-({[3-(trifluoromethyl)phenyl]amino}methylidene)-3,4-dihydro-2H-1,4-benzothiazin-3-one (CAS 338417-13-3)
- 1-Chloro-2-(3-phenylpropioloyl)anthracene-9,10-dione (CAS 680603-25-2)
- 2-Chloro-5-{5-(methylthio)-4-[3-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}pyridine (CAS 680216-99-3)
- 5-Chloro-4-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}pyrimidin-2-amine (CAS 499796-54-2)
- 6-(4-Chloro-3-methylphenoxy)-6,7-dihydro-5H-dibenzo[d,f][1,3,2]diazaphosphepine 6-oxide (CAS 68521-36-8)
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Recommended Standards
- 4-(4-Chlorophenyl)-N-[4-(trifluoromethoxy)phenyl]-1,3-thiazol-2-amine (CAS 914660-36-9)
- N-((2S,3R,4R,5R,6R)-2-((6-chloro-1H-indol-3-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)acetamide (CAS 501432-61-7)
- AM-0902, 99% (HPLC) (CAS 1883711-97-4)
- 3-(5-(4-Chlorophenyl)furan-2-yl)-N-(3-nitrophenyl)propanamide (CAS 853312-05-7)
- 3-(1h-1,2,3-Benzotriazol-1-yl)propanenitrile (CAS 6946-09-4)
- 2-Trifluoromethyl-2-propanol (CAS 507-52-8)
- 6-Bromopyrazolo[1,5-a]pyrimidin-3-amine (CAS 1508567-18-7)
- 2-Methoxyisonicotinamide (CAS 105612-50-8)
- 1-(1H-1,2,4-triazol-1-yl)propan-2-amine (CAS 883545-31-1)
- 2-((Dimethylamino)methyl)-4-isopropylpyrimidine-5-carboxylic acid (CAS 1510948-07-8)
- N-(4H-1,2,4-triazol-4-yl)naphthalene-2-sulfonamide (CAS 331434-23-2)
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