5-Chloro-4-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}pyrimidin-2-amine CAS 499796-54-2
| CAS No. | 499796-54-2 |
| Molecular Formula | C15H10ClF3N4S |
| Molecular Weight | 370.78 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 370.78 g/mol gives 5-Chloro-4-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}pyrimidin-2-amine distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies 5-Chloro-4-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}pyrimidin-2-amine (CAS 499796-54-2), a certified reference material (molecular formula C15H10ClF3N4S, MW 370.78 g/mol) for analytical method development and quality control.
5-Chloro-4-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}pyrimidin-2-amine (C15H10ClF3N4S) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-Chloro-4-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}pyrimidin-2-amine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H10ClF3N4S |
| Molecular Weight | 370.78 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Chloro Standards
- (2E)-7-Chloro-2-({[2-(trifluoromethyl)phenyl]amino}methylidene)-3,4-dihydro-2H-1,4-benzothiazin-3-one (CAS 338417-10-0)
- (2E)-7-Chloro-2-({[3-(trifluoromethyl)phenyl]amino}methylidene)-3,4-dihydro-2H-1,4-benzothiazin-3-one (CAS 338417-13-3)
- 1-Chloro-2-(3-phenylpropioloyl)anthracene-9,10-dione (CAS 680603-25-2)
- 2-Chloro-5-{5-(methylthio)-4-[3-(trifluoromethyl)phenyl]-4H-1,2,4-triazol-3-yl}pyridine (CAS 680216-99-3)
- 5-Chloro-4-{4-methyl-2-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}pyrimidin-2-amine (CAS 499795-98-1)
- 6-(4-Chloro-3-methylphenoxy)-6,7-dihydro-5H-dibenzo[d,f][1,3,2]diazaphosphepine 6-oxide (CAS 68521-36-8)
- 4-((5-Chloro-6-oxo-1-(p-tolyl)-1,6-dihydropyridazin-4-yl)oxy)-3-methoxybenzaldehyde (CAS 881601-10-1)
- 4-((5-Chloro-6-oxo-1-phenyl-1,6-dihydropyridazin-4-yl)oxy)-3-ethoxybenzaldehyde (CAS 866767-60-4)
Recommended Standards
- N-((2S,3R,4R,5R,6R)-2-((6-chloro-1H-indol-3-yl)oxy)-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)acetamide (CAS 501432-61-7)
- 4-(4-Chlorophenyl)-N-[4-(trifluoromethoxy)phenyl]-1,3-thiazol-2-amine (CAS 914660-36-9)
- AM-0902, 99% (HPLC) (CAS 1883711-97-4)
- 3-(5-(4-Chlorophenyl)furan-2-yl)-N-(3-nitrophenyl)propanamide (CAS 853312-05-7)
- 3,4,5,6-Tetrachloropicolinic acid (CAS 10469-09-7)
- 6-(4-Aminopiperidin-1-yl)-N-cyclopropylpyrimidin-4-amine;hydrochloride (CAS 1185317-86-5)
- 1-Androstenedione (CAS 571-40-4)
- 2-(Pyridin-2-yl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine hydrochloride (CAS 1207175-11-8)
- 2-((2-(Quinolin-8-yl)hydrazono)methyl)quinolin-8-ol (CAS 24430-56-6)
- Voglibose Impurity 6 (CAS 38231-86-6)
- 3-Bromo-5-fluoroindazole-1-carboxylic acid tert-butyl ester (CAS 885271-57-8)
- 4-((5-Bromo-2-methoxybenzylidene)amino)-3-(pyridin-2-yl)-1H-1,2,4-triazole-5(4H)-thione (CAS 497823-53-7)
- (Butan-2-yl)[(4-chlorophenyl)methyl]amine (CAS 46234-40-6)
- Neuropeptide Y (13-36) (porcine) (CAS 113662-54-7)
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