Estradiol Impurity 41 CAS 4999-78-4

Purity 97%+In StockPharmacopoeial Impurity Standards
CAS No.4999-78-4
Molecular FormulaC18H23O5S
Molecular WeightN/A
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Estradiol Impurity 41 CAS 4999-78-4 chemical structure

Description

CATO supplies Estradiol Impurity 41 (CAS 4999-78-4), a pharmacopoeial impurity reference standard (molecular formula C18H23O5SNa, MW 374.43 g/mol) used for the identification and quantification of trace impurities in APIs.

Structurally, Estradiol Impurity 41 (C18H23O5SNa) contains a flavonoid core, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 7.5, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 374.43 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC18H23O5S Na
Molecular Weight374.43 g/mol
Purity97%+
StorageStore at 2-8°C, protect from light, keep sealed and dry
Solubility (reference)Soluble in methanol, acetonitrile, DMSO, water (slightly soluble)
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)7.5
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1958
Sulfur Atoms1

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