Sofosbuvir Ph.Int Impurity B(Chloro Sofosbuvir) CAS 1496552-51-2
| CAS No. | 1496552-51-2 |
| Molecular Formula | C22H29ClN3O9P |
| Molecular Weight | 545.91 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 545.91 g/mol gives Sofosbuvir Ph.Int Impurity B(Chloro Sofosbuvir) distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Sofosbuvir Ph.Int Impurity B(Chloro Sofosbuvir) (CAS 1496552-51-2) is a certified pharmaceutical impurity reference standard with the molecular formula C22H29ClN3O9P and a molecular weight of 545.91 g/mol.
Based on its molecular formula C22H29ClN3O9P, Sofosbuvir Ph.Int Impurity B(Chloro Sofosbuvir) contains a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 545.91 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Sofosbuvir Ph.Int Impurity B(Chloro Sofosbuvir) meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H29ClN3O9P |
| Molecular Weight | 545.91 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Sofosbuvir Standards
- Sofosbuvir Impurity 71 (CAS CATO-C4X-105271)
- Sofosbuvir Impurity 10 (CAS 863329-63-9)
- Sofosbuvir D6 (CAS 1868135-06-1)
- Sofosbuvir-13C-d3 (CAS 2070009-25-3)
- Sofosbuvir Impurity 103 (CAS CATO-C4X-1052103)
- Sofosbuvir (CAS 1190307-88-0)
- Sofosbuvir Impurity 22 (CAS 1190308-01-0)
- Sofosbuvir Impurity 23 (CAS CATO-C4X-105223)
Recommended Standards
- (2S)-isopropyl2-(((((2R,3R,4R,5R)-4-chloro-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate (CAS 1496551-77-9)
- Heptadecafluoro-n-octyl Iodide (CAS 507-63-1)
- (5E)-1-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}ethyl)-5-{[(4-phenoxyphenyl)amino]methylidene}-1,3-diazinane-2,4,6-trione (CAS 339101-11-0)
- 3-(((4-Chlorophenyl)sulfonyl)methyl)-N'-(1-(6-fluoropyridin-2-yl)piperidin-4-ylidene)-4-nitrobenzohydrazide (CAS 339016-42-1)
- Pidotimod Impurity 11 (CAS CATO-C4X-107811)
- Voriconazole Impurity 86 (CAS CATO-C4X-136686)
- Dapagliflozin Impurity 102 (CAS CATO-C4X-1138102)
- 6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (CAS 76824-86-7)
- 2-chloro-3-oxobutaneamide (CAS 67271-66-3)
- 6,8-Difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (CAS 228728-19-6)
- ethyl 8,9-diazatricyclo[4.3.0.0²⁴]nona-1(6),7-diene-7-carboxylate (CAS 1229028-83-4)
- Vardenafil Impurity 54 (CAS 1810028-99-9)
- 3-(2-Bromophenyl)cyclohexanone (CAS 1379320-69-0)
- (Thr(PO3H2)231)-Tau Peptide (225-237) trifluoroacetate salt (CAS 1670270-09-3)
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