Tulobuterol Impurity N1 CAS 5000-66-8
| CAS No. | 5000-66-8 |
| Molecular Formula | C8H6BrClO |
| Molecular Weight | 233.49 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Tulobuterol Impurity N1 (CAS 5000-66-8, C8H6BrClO) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a hydroxyl group, an ether linkage, chlorine/bromine substitution, an aromatic ring system, Tulobuterol Impurity N1 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 233.49 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C8H6BrClO |
| Molecular Weight | 233.49 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl/Br-containing |
Related Tulobuterol Standards
- Tulobuterol Impurity N9 (CAS 41011-01-2)
- Tulobuterol Impurity N2 (CAS 536-38-9)
- Tulobuterol Impurity 23 (CAS CATO-C4X-213423)
- Tulobuterol Impurity 5 (CAS 6314-52-9)
- Tulobuterol Impurity N4 (CAS 117538-45-1)
- Tulobuterol Impurity N5 (CAS 72702-57-9)
- Tulobuterol Impurity 10 (CAS 69240-94-4)
- Tulobuterol Impurity 12 (CAS 14185-28-5)
Recommended Standards
- 7-Bromo-6-chloro-2,3-dihydro-1H-pyrrolo[3,2-c]pyridine (CAS 80862-18-6)
- 1-Bromo-3-(3-chloropropyl)benzene (CAS 1057673-67-2)
- 5-Chloro-2-(bromomethyl)benzaldehyde (CAS 886041-44-7)
- 4-Bromo-2,5-dimethylbenzyl chloride (CAS 108480-48-4)
- Landiolol Impurity 90 (CAS CATO-C4X-262190)
- Cilastatin Impurity 37 (CAS CATO-C4X-196037)
- Flucloxacillin Monohydrate EP Impurity G (CAS CATO-C4X-164710)
- Ethyl 5-(bis(2-hydroxyethyl)amino)-1H-indole-3-carboxylate (CAS 7150-82-5)
- N-(7-oxo-4,5,6,7-tetrahydrobenzo[d]thiazol-2-yl)acetamide (CAS 154404-97-4)
- 2-(2-(3-Bromophenyl)-2-oxoethyl)isoindoline-1,3-dione (CAS 500356-85-4)
- 6-(3-Fluorobenzyl)-2,5,7-trimethylpyrazolo[1,5-a]pyrimidine (CAS 439111-21-4)
- H-Nva-OH (CAS 6600-40-4)
- Acid Violet 49 (CAS 1694-09-3)
- Vancomycin Hexapeptide (CAS 115236-65-2)
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