Atorvastatin EP Impurity E CAS 501121-34-2
| CAS No. | 501121-34-2 |
| Molecular Formula | C33H35FN2O5 |
| Molecular Weight | 558.64 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Atorvastatin EP Impurity E (CAS 501121-34-2) is a certified pharmaceutical impurity reference standard with the molecular formula C33H35FN2O5 and a molecular weight of 558.64 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Atorvastatin EP Impurity E is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 558.64 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Atorvastatin EP Impurity E meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C33H35FN2O5 |
| Molecular Weight | 558.64 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 17.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Atorvastatin Standards
- Atorvastatin EP Impurity E (CAS 110862-48-1（Relative）)
- Atorvastatin EP Impurity B (CAS 887324-52-9)
- Atorvastatin (CAS 134523-00-5)
- Atorvastatin Impurity 100 (CAS CATO-C4X-1132100)
- Atorvastatin Impurity 133 (CAS CATO-C4X-1132133)
- Atorvastatin Impurity 134 (CAS CATO-C4X-1132134)
- Atorvastatin Impurity 15 (CAS 906552-19-0)
- Atorvastatin EP Impurity O (CAS 887196-30-7)
Recommended Standards
- (S)-[2’-(2-Methoxybenzyl)-[1,1’-binaphthalen]-2-yl]diphenylphosphine (CAS 1454319-48-2)
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- 1,1-[(1,1-Dimethylethyl)[[(1R,2E,4E)-5-iodo-1-[3-(trimethylsilyl)-2-propyn-1-yl]-2,4-pentadien-1-yl]oxy]silylene]bis-benzene (CAS 1220354-19-7)
- (S)-3-(3-Methoxy-4-(4-((1,4,5,6-tetrahydropyrimidin-2-yl)amino)piperidin-1-yl)benzamido)-2-(phenylsulfonamido)propanoic acid (CAS 247034-73-7)
- HO-Ste-γGlu-AEEA-OH (CAS CATO-C4X-2226278)
- Tolvaptan Impurity 80 (CAS CATO-C4X-195580)
- Amphotericin B EP Impurity C (CAS CATO-C4X-18444)
- 4-Iodo-N-methylbenzamide (CAS 89976-43-2)
- (R)-5-(1-amino-3-hydroxypropyl)-2-methoxyphenol (CAS 1212821-13-0)
- 4,4'-(Furan-2-ylmethylene)bis(N,N-dimethylaniline) (CAS 57751-98-1)
- 2,2-Difluoro-N-(4-methoxybenzyl)ethan-1-amine (CAS 1184429-97-7)
- (5-Methyl-[1,3,4]oxadiazol-2-ylsulfanyl)-acetic acid 0403AF 842965-64-4 C5H6N2O3S (CAS 842965-64-4)
- 3-(Prop-2-yn-1-yloxy)benzothioamide (CAS 1193389-35-3)
- Insulin Pork(≥27 USP units/mg) (CAS 12584-58-6)
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