Atorvastatin Impurity 133 CAS CATO-C4X-1132133
| CAS No. | CATO-C4X-1132133 |
| Molecular Formula | C33H33FN2O5 |
| Molecular Weight | 556.62 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Atorvastatin Impurity 133 (CAS CATO-C4X-1132133, C33H33FN2O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Atorvastatin Impurity 133 (C33H33FN2O5) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Atorvastatin Impurity 133 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C33H33FN2O5 |
| Molecular Weight | 556.62 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 18.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Atorvastatin Standards
- Atorvastatin Impurity 100 (CAS CATO-C4X-1132100)
- Atorvastatin Impurity 134 (CAS CATO-C4X-1132134)
- Atorvastatin Impurity 15 (CAS 906552-19-0)
- Atorvastatin EP Impurity O (CAS 887196-30-7)
- 5-Oxo Atorvastatin (CAS 1391052-82-6)
- Atorvastatin Impurity 34 (CAS CATO-C4X-113234)
- Atorvastatin Impurity 93 (CAS 163217-74-1)
- Atorvastatin Impurity 94 (CAS 163217-70-7)
Recommended Standards
- 3,5-Di([2,2':6',2''-terpyridin]-4'-yl)phenol (CAS 686780-96-1)
- 1,3-Bis(1-(7-nitroquinazolin-4-yl)piperidin-4-yl)propane (CAS 52791-15-8)
- Irinotecan Impurity 29 (CAS CATO-C4X-166729)
- Candesartan Impurity 9 (CAS CATO-C4X-15729)
- Ioversol Impurity 1 (CAS 134768-85-7)
- Ceritinib Impurity 65 (CAS CATO-C4X-104865)
- Escitalopram EP impurity E D-PTTA (CAS CATO-C4X-110988)
- 1-Boc-7-fluoro-1H-indazole (CAS 1305320-59-5)
- [1,2,4]Triazolo[4,3-a]pyridin-6-amine hydrochloride (CAS 1352443-03-8)
- Isosorbide Dinitrate, Diluted EP Impurity C (CAS 16051-77-7)
- (4-(Mercaptomethyl)phenyl)boronic acid (CAS 847801-60-9)
- 3-Ethoxy-4-(3-phenylpropoxy)benzaldehyde (CAS 656810-26-3)
- (S)-2-Methyldecanoic acid (CAS 74036-83-2)
- 302798-54-5 (Leu31,Pro34)-Neuropeptide Y (13-36) (human, rat) MFCD00672463 (CAS 302798-54-5)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com