3-Fluoro-4-(2,2,2-trifluoroethoxy)benzaldehyde CAS 502486-73-9
| CAS No. | 502486-73-9 |
| Molecular Formula | C9H6F4O2 |
| Molecular Weight | 222.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-Fluoro-4-(2,2,2-trifluoroethoxy)benzaldehyde (CAS 502486-73-9) is a high-purity analytical reference standard with the molecular formula C9H6F4O2 and a molecular weight of 222.14 g/mol.
3-Fluoro-4-(2,2,2-trifluoroethoxy)benzaldehyde (C9H6F4O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H6F4O2 |
| Molecular Weight | 222.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | F-containing |
Related Fluoro Standards
- 1-(4-Fluoro-3-(trifluoromethyl)phenyl)urea (CAS 1000588-77-1)
- 3-fluoro-2-methyl-4-(trifluoromethyl)benzoic acid (CAS 1070761-76-0)
- 2-Fluoro-5-(trifluoromethyl)benzohydrazide (CAS 1079843-54-1)
- 1-(3-Fluoro-4-(trifluoromethoxy)phenyl)ethan-1-one (CAS 1174006-08-6)
- 2-Fluoro-5-methyl-4-(trifluoromethyl)benzoic acid (CAS 1323955-61-8)
- 2-Fluoro-3-methoxy-4-(trifluoromethyl)benzaldehyde (CAS 1352719-37-9)
- 1-(3-Fluoro-5-(trifluoromethoxy)phenyl)ethan-1-one (CAS 1352999-53-1)
- 4-Fluoro-3-methyl-5-(trifluoromethyl)benzoic acid (CAS 1373920-63-8)
Recommended Standards
- 3-(1,1,2,2-Tetrafluoroethoxy)benzaldehyde (CAS 35295-35-3)
- 3-Fluoro-4-(trifluoromethyl)phenylacetic Acid (CAS 238754-67-1)
- 2-Fluoro-6-(2,2,2-trifluoroethoxy)benzaldehyde (CAS 907609-06-7)
- 4-(1,1,2,2-Tetrafluoroethoxy)benzaldehyde (CAS 35295-36-4)
- 2h-Chromene-3-sulfonyl chloride (CAS 1235441-16-3)
- N-[4-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]pyrazine-2-carboxamide (CAS 2246808-60-4)
- Trimethylsulfonium iodide (CAS 2181-42-1)
- (3R,5R)-1-(tert-Butylsulfonyl)-5-(2,5-difluorophenyl)pyrrolidin-3-ol (CAS 1887746-44-2)
- 3-Bromo-4-cyclopropoxybenzonitrile (CAS 1243367-91-0)
- Methyl 4-((2-aminophenyl)amino)-2,5-dihydrothiophene-3-carboxylate (CAS 61325-23-3)
- Bis(hydroxymethyl)diphenylphosphonium chloride (CAS 96776-80-6)
- 5-Ethyl-2-fluorophenol (CAS 891843-05-3)
- Tetrahydro-2H-thiopyran-4-carboxylic acid 1,1-dioxide (CAS 64096-87-3)
- [2-31]-Semaglutide C (x TFA Salt) (CAS CATO-C4X-2226118)
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