Vitamin K1 Impurity 35 CAS 50281-47-5
| CAS No. | 50281-47-5 |
| Molecular Formula | C33H50O3 |
| Molecular Weight | 494.75 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Vitamin K1 Impurity 35.
As a process- or degradation-related impurity, Vitamin K1 Impurity 35 (CAS 50281-47-5, C33H50O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Vitamin K1 Impurity 35 (C33H50O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C33H50O3 |
| Molecular Weight | 494.75 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1971 |
Related Vitamin Standards
- Vitamin K1 Hydroperoxide Impurity 2 (CAS 23397-22-0)
- Vitamin K1 Hydroperoxide (CAS CATO-C4X-22073)
- Pre-Vitamin D3 Octanoate (CAS 927822-17-1)
- Vitamin D3 Octanoate (CAS 927822-16-0)
- Vitamin D2 (CAS 1784-46-9)
- Vitamin K1-d7 2,3-Epoxide (CAS 1795136-97-8)
- Vitamin K1 Impurity 47 (CAS 2682052-39-5)
- Vitamin K1 Impurity 43 (CAS 1181-23-3)
Recommended Standards
- (E)-5-((4-chlorophenyl)thio)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde O-(3,4-dichlorobenzyl) oxime (CAS 321553-45-1)
- 1-Oxo-1-phenylpropan-2-yl 6-bromo-2-(4-chlorophenyl)quinoline-4-carboxylate (CAS 355421-54-4)
- (E)-5-((4-chlorophenyl)thio)-1-methyl-3-(trifluoromethyl)-1H-pyrazole-4-carbaldehyde O-(2,6-dichlorobenzyl) oxime (CAS 321533-81-7)
- 1,4-Bis(dodecyloxy)-2,5-diethynylbenzene (CAS 152270-00-3)
- Canagliflozin Impurity 67 (CAS CATO-C4X-112367)
- Obeticholic Acid Impurity 11 (CAS CATO-C4X-115311)
- Terbinafine EP Impurity A HCl (CAS 65473-13-4)
- exo-2-(Boc-amino)-8-azabicyclo[3.2.1]octane (CAS 1408074-85-0)
- Methyl 6-(3-chlorophenyl)-5,7-dioxo-hexahydroimidazo[1,5-c][1,3]thiazole-3-carboxylate (CAS 1008207-83-7)
- 3-Chloro-N-(4-(N-(6-chloropyridazin-3-yl)sulfamoyl)phenyl)propanamide (CAS 900711-21-9)
- 9H-Fluorene-9-thiol (CAS 19552-08-0)
- (5-Methyl-2-(1-methylcyclohex-3-en-1-yl)oxazol-4-yl)methanol (CAS 89724-37-8)
- [1-(Benzenesulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]boronic acid (CAS 1373273-50-7)
- C-Peptide (Proinsulin) (CAS 59112-80-0)
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