Naproxen EP Impurity H CAS 5111-66-0
| CAS No. | 5111-66-0 |
| Molecular Formula | C11H10O2 |
| Molecular Weight | 174.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 174.20 g/mol gives Naproxen EP Impurity H distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Naproxen EP Impurity H (CAS 5111-66-0, C11H10O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Naproxen EP Impurity H (C11H10O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Naproxen EP Impurity H under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C11H10O2 |
| Molecular Weight | 174.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
Related Naproxen Standards
- Naproxen Impurity 29 (CAS 91059-47-1)
- Naproxen Nitrile Impurity (CAS 67886-70-8)
- Naproxen Impurity 19 (CAS CATO-C4X-170819)
- Naproxen EP Impurity M (CAS 93-04-9)
- Naproxen Impurity 53 (CAS 150493-03-1)
- Naproxen Impurity 5 (CAS 17696-64-9)
- Naproxen Impurity 16 (CAS 34352-92-6)
- Naproxen EP Impurity L (CAS 3900-45-6)
Recommended Standards
- Domperidone Impurity 31 (CAS 95926-75-3)
- Butylphthalide Impurity 19 (CAS 17369-59-4)
- Domperidone Impurity 22 (CAS 52099-72-6)
- Rotigotine Impurity 41 (CAS CATO-C4X-192741)
- Pitolisant impurity 19 (CAS CATO-C4X-252019)
- Lactulose Impurity F (CAS 3343-53-1&136272-61-2)
- Pitavastatin Impurity 112 (CAS 1187966-91-1)
- 2,6-Diamino-4-isopropyl-4H-thiopyran-3,5-dicarbonitrile (CAS 180537-84-2)
- (3-Bromo-4-((3,5-dimethylbenzyl)oxy)phenyl)methanol (CAS 1135283-86-1)
- 4-Chloro-2-methylphthalazin-1(2H)-one (CAS 40227-54-1)
- 2-(2-Chloro-4,5-dimethylphenoxy)acetohydrazide (CAS 1706463-27-5)
- 1-((2-Chloroethyl)sulfonyl)pentane (CAS 59681-99-1)
- 2,4-Dichloro-5-ethyl-6-methylpyrimidine (CAS 861033-35-4)
- D-Ser32-Tirzepatide (CAS CATO-CPTD788677)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com