Benzenesulfonic Impurity 5 CAS 51395-19-8
| CAS No. | 51395-19-8 |
| Molecular Formula | C12H14N4O3S |
| Molecular Weight | 294.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Benzenesulfonic Impurity 5 (CAS 51395-19-8, C12H14N4O3S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Benzenesulfonic Impurity 5 (C12H14N4O3S) contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 294.33 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C12H14N4O3S |
| Molecular Weight | 294.33 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1971 |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Benzenesulfonic Standards
- Benzenesulfonic Impurity 6 (CAS 51395-20-1)
- Benzenesulfonic Anhydride (CAS 512-35-6)
- Benzenesulfonic acid, 2-(trifluoromethyl)-, 2-(2,2-difluoroethylidene)hydrazide (CAS 2245235-35-0)
- Benzenesulfonic Impurity 3 (CAS 1352414-81-3)
- Benzenesulfonic (2S)-4-bromopyrrolidine-2-carboxylic anhydride (CAS 61264-65-1)
- Benzenesulfonic acid, 4-(bromomethyl)-, sodium salt (1:1) (CAS 32014-22-5)
- Benzenesulfonic acid, 2-(trifluoromethyl)-, 2-(2,2,2-trifluoroethylidene)hydrazide (CAS 2236129-81-8)
- Benzenesulfonic (2S)-4-(dimethylamino)-1-methylpyrrolidine-2-carboxylic anhydride (CAS 62305-75-3)
Recommended Standards
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- 3-(2-Chlorophenyl)-4,5-dihydroisoxazol-5-ol (CAS 112853-60-8)
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- 3-Methoxy-N-[2-(2-methoxyphenoxy)ethyl]aniline (CAS 1040690-71-8)
- Allyl 3-((3-(benzyloxy)-2-(ethoxycarbonyl)-4-oxopyridin-1(4H)-yl)amino)morpholine-4-carboxylate (CAS 2119729-44-9)
- Palbociclib Impurity 136 (CAS CATO-C4X-1125136)
- Methyl (r)-3-amino-3-(3-fluorophenyl)propanoate (CAS 1213403-50-9)
- (Tyr?)-C-Peptide (human) (CAS 57327-90-9)
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