Rifabutin EP Impurity B CAS 51756-80-0
| CAS No. | 51756-80-0 |
| Molecular Formula | C37H46N2O12 |
| Molecular Weight | 710.77 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Rifabutin EP Impurity B meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Rifabutin EP Impurity B (CAS 51756-80-0, C37H46N2O12) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Rifabutin EP Impurity B (C37H46N2O12) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 16.0, corresponding to approximately 16 ring(s) or double-bond equivalent(s). With a molecular weight of 710.77 g/mol, it falls into the high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C37H46N2O12 |
| Molecular Weight | 710.77 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1971 |
| Nitrogen Atoms | 2 |
Related Rifabutin Standards
- Rifabutin EP Impurity D (CAS 62041-01-4)
- Rifabutin EP Impurity E (CAS 100324-63-8)
- Rifabutin Impurity 13 (CAS CATO-C4X-251213)
- Rifabutin Impurity 14 (CAS CATO-C4X-251214)
- Rifabutin EP Impurity C (CAS 2241829-23-0)
- Rifabutin Impurity 12 (14-epi-Rifabutin) (CAS CATO-C4X-251212)
- Rifabutin (CAS 72559-06-9)
- Rifabutin-d7 (CAS CATO-C4X-25121)
Recommended Standards
- 7-(((1R,2S,3E,5Z)-10-(4-Acetyl-3-hydroxy-2-propylphenoxy)-1-hydroxy-1-(3-(trifluoromethyl)phenyl)deca-3,5-dien-2-yl)thio)-4-oxo-4H-chromene-2-carboxylic acid (CAS 151581-24-7)
- Cefcapene Impurity 103 (CAS CATO-C4X-1824103)
- Citalopram Impurity 85 (CAS CATO-C4X-110985)
- Ibrutinib Impurity 16 (CAS CATO-C4X-106416)
- Entacapone impurity 50 (CAS CATO-C4X-162950)
- Apixaban Impurity 25 (CAS CATO-C4X-108825)
- Rosuvastatin Impurity 88 (CAS CATO-C4X-116988)
- Afatinib (CAS 439081-18-2)
- N-Succinimidyl 4-[4-(Dimethylamino)phenylazo]benzoate (CAS 146998-31-4)
- 1-Methyl-5-(thiophen-2-yl)-1H-pyrazole (CAS 876316-68-6)
- 2-(3-(Trifluoromethyl)-1h-pyrazol-1-yl)acetonitrile (CAS 1006348-71-5)
- 2-((1,3-Dimethyl-1H-pyrazolo[3,4-b]quinolin-4-yl)amino)acetic acid (CAS 105774-29-6)
- 4-Bromo-N,N-dimethyl-1H-pyrazole-1-sulfonamide (CAS 214342-72-0)
- C-Peptide 2 (rat) (CAS 41594-08-5)
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