Afatinib CAS 439081-18-2
| CAS No. | 439081-18-2 |
| Molecular Formula | C24H25ClFN5O3 |
| Molecular Weight | 485.94 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO supplies Afatinib (CAS 439081-18-2), a certified reference material (molecular formula C24H25ClFN5O3, MW 485.94 g/mol) for analytical method development and quality control.
The molecular framework of Afatinib (C24H25ClFN5O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C24H25ClFN5O3 |
| Molecular Weight | 485.94 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
Related Afatinib Standards
- Afatinib (CAS 850140-72-6)
- Afatinib impurity 12 (CAS 1680184-59-1)
- Afatinib Impurity 3 (CAS 945553-91-3)
- Afatinib Impurity 71 (CAS CATO-C4X-100671)
- Afatinib Impurity 24 (CAS CATO-C4X-100624)
- Afatinib Impurity 63 (CAS CATO-C4X-100663)
- Afatinib Impurity 94 (CAS CATO-C4X-100694)
- Afatinib Impurity 36 (CAS CATO-C4X-100636)
Recommended Standards
- Canertinib (CAS 267243-28-7)
- (R)-N-(4-((3-Chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide (CAS 439081-17-1)
- 2-Chloro-4-(methylsulfonyl)-N-(4-((3-(trifluoromethyl)phenyl)thio)phenyl)benzamide (CAS 339104-86-8)
- Dacomitinib Impurity 1 (CAS CATO-C4X-20861)
- (2-Chlorophenyl)(3-(methylamino)piperidin-1-yl)methanone hydrochloride (CAS 1834499-97-6)
- 1-(2-Chloro-3-hydroxypyridin-4-yl)ethanone (CAS 1256818-94-6)
- [2-(propan-2-yloxy)phenyl]methanamine (CAS 227199-51-1)
- Linagliptin Impurity 39 (CAS 184637-48-7)
- 6-Bromo-2-chloro-3-iodotoluene (CAS 1799612-41-1)
- Methyl 3-phenyl-2-(trifluoroacetamido)propanoate (CAS 2612-19-3)
- 2-Amino-5-bromo-3-methoxybenzonitrile (CAS 176718-54-0)
- 5-Amino-4,6-dibromopyridine-2-carbonitrile (CAS 1429510-81-5)
- (((1-(2-Amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-3-hydroxypropan-2-yl)oxy)methyl)phosphonic acid (CAS 113852-36-1)
- [Glu]17-Semaglutide (CAS CATO-CPTD788604)
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