Carteolol EP Impurity D CAS 51781-13-6
| CAS No. | 51781-13-6 |
| Molecular Formula | C12H14ClNO3 |
| Molecular Weight | 255.70 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Carteolol EP Impurity D.
As a process- or degradation-related impurity, Carteolol EP Impurity D (CAS 51781-13-6, C12H14ClNO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Carteolol EP Impurity D is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 255.70 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Carteolol EP Impurity D meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H14ClNO3 |
| Molecular Weight | 255.70 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1971 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Carteolol Standards
- Carteolol EP Impurity F (CAS 2748462-60-2)
- Carteolol Impurity 19 (CAS CATO-C4X-228719)
- Carteolol Impurity 20 (CAS CATO-C4X-228720)
- Carteolol EP Impurity G (CAS 54945-72-1)
- Carteolol Impurity 22 (CAS CATO-C4X-228722)
- Carteolol Impurity 31 (CAS CATO-C4X-228731)
- Carteolol EP Impurity H (CAS 62330-84-1)
- Carteolol EP Impurity C (CAS 51781-14-7)
Recommended Standards
- Lornoxicam Impurity 6 (CAS 70374-36-6)
- 4-Chloro-2-methyl-8-trifluoromethyl-quinoline (CAS 140908-89-0)
- Lornoxicam Impurity 33 (CAS 941239-79-8)
- 4-Chloro-2-methyl-7-(trifluoromethyl)quinoline (CAS 18529-09-4)
- Trifluridine Impurity 6 (CAS 129664- 48-8)
- Cefodizime Impurity 14 (CAS CATO-C4X-180614)
- Trospium Impurity N2 (CAS 16444-19-2)
- Glutathione EP Impurity A (CAS 19246-18-5)
- (2-Butoxyethyl)benzene (CAS 5331-14-6)
- 4-(Difluoromethoxy)-2-(4-fluorophenyl)pyridine (CAS 1214347-18-8)
- 3-Chloro-3-(4-chlorophenyl)-3H-diazirine (CAS 39184-66-2)
- Rivaroxaban Impurity 122 (CAS CATO-C4X-1090122)
- Ethyl 2-amino-4-(methylthio)pyrimidine-5-carboxylate (CAS 15400-51-8)
- Tau Peptide (268-282) trifluoroacetate salt (CAS 330456-37-6)
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