5-(Bis(2-chloroethyl)amino)-6-methylpyrimidine-2,4(1H,3H)-dione CAS 520-09-2
| CAS No. | 520-09-2 |
| Molecular Formula | C9H13Cl2N3O2 |
| Molecular Weight | 266.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 266.12 g/mol gives 5-(Bis(2-chloroethyl)amino)-6-methylpyrimidine-2,4(1H,3H)-dione distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
5-(Bis(2-chloroethyl)amino)-6-methylpyrimidine-2,4(1H,3H)-dione (CAS 520-09-2) is a high-purity analytical reference standard with the molecular formula C9H13Cl2N3O2 and a molecular weight of 266.12 g/mol.
The molecular framework of 5-(Bis(2-chloroethyl)amino)-6-methylpyrimidine-2,4(1H,3H)-dione (C9H13Cl2N3O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-(Bis(2-chloroethyl)amino)-6-methylpyrimidine-2,4(1H,3H)-dione meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H13Cl2N3O2 |
| Molecular Weight | 266.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Bis Standards
- 5-(Bis(2-chloroethyl)amino)-3-methylpyrimidine-2,4(1H,3H)-dione (CAS 62785-09-5)
- 1-(2-Chloroethyl)-2-iodobenzene (CAS 1037075-33-4)
- 1-(1-Chloroethyl)-4-iodobenzene (CAS 58114-08-2)
- 1-(2-Chloroethyl)-3-(4-(trifluoromethyl)phenyl)urea (CAS 13908-39-9)
- 1-(2-Chloroethyl)-3-(3-(trifluoromethyl)phenyl)urea (CAS 500546-66-7)
- 1-[3-(2-chloroethyl)phenyl]octan-1-one (CAS 841251-39-6)
- 1-(2-Chloroethyl)-3-(3,4-dichlorophenyl)urea (CAS 15145-37-6)
- 1-(2-Chloroethyl)-3-(3-(difluoromethoxy)phenyl)urea (CAS 1427460-88-5)
Recommended Standards
- Pentafluorophenyl Fluorosulfonate (CAS 60129-86-4)
- 4-iodo-1-methyl-1H-indazole (CAS 935661-15-7)
- α-(Fluoromethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenemethanol (CAS 2845281-96-9)
- 4-Chloro-N-(4-chlorophenyl)benzamide (CAS 39193-06-1)
- 8-Chloro-4,4-dimethylthiochroman-6-carbaldehyde 1,1-dioxide (CAS 1350761-72-6)
- 2-(Sec-butylamino)propane-1,3-diol (CAS 1483179-80-1)
- Methyl 2-hydroxy-3-(thiophen-2-yl)propanoate (CAS 1181600-87-2)
- 1,2,3,4-Tetrachloro-9-methoxyanthracene (CAS 61601-19-2)
- 4-(Chloromethyl)-1-methoxy-5-methylhexane (CAS 1485535-65-6)
- 4-Chloro-5-methyl-3-(1,2,2,2-tetrafluoro-1-(perfluoropropoxy)ethyl)-1H-pyrazole (CAS 247113-93-5)
- Potassium 2-Chloroisonicotinoyltrifluoroborate (CAS 1622923-59-4)
- 6-Bromo-1-(2,4-dimethylphenyl)-2H-isoindole (CAS 358641-85-7)
- (s)-6-Fluoro-2-(pyrrolidin-3-yl)isoindolin-1-one hydrochloride (CAS 1439894-61-7)
- KALA Amphipathic Peptide (CAS 187987-64-0)
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