Terbutaline Impurity 6 HCl CAS 52144-90-8(Free Base)
| CAS No. | 52144-90-8(Free Base) |
| Molecular Formula | C26H29NO3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 439.98 g/mol gives Terbutaline Impurity 6 HCl distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Terbutaline Impurity 6 HCl (CAS 52144-90-8(Free Base), C26H29NO3HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Terbutaline Impurity 6 HCl (C26H29NO3HCl) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C26H29NO3 HCl |
| Molecular Weight | 439.98 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Terbutaline Standards
- Terbutaline-d9 (CAS 1189658-09-0)
- Terbutaline impurity 115 (CAS 1217895-73-2)
- Terbutaline impurity 101 (CAS 1226543-90-3)
- Terbutaline EP Impurity C HCl (CAS 1246815-70-2)
- Terbutaline impurity 71 (CAS 13262-38-9)
- Terbutaline Impurity 13 (CAS 13494-10-5)
- Terbutaline EP impurity C (CAS 139508-58-0)
- Terbutaline EP Impurity C (Hydrobromide) (CAS 139508-58-0 (free base))
Recommended Standards
- Pemafibrate Impurity 80 (CAS CATO-C4X-290380)
- Pefloxacin Mesilate Dihydrate EP Impurity B (CAS 70458-73-0)
- Upadacitinib Impurity 140 (CAS CATO-C4X-2405140)
- 5-(Methothio)thiophene-2-boronic acid pinacol ester (CAS 1172999-13-1)
- Methyl 5-Bromo-2-(bromomethyl)benzoate (CAS 79670-17-0)
- Triarylsulfonium hexafluoroantimonate mixture (CAS 109037-75-4)
- 4-(Difluoromethyl)-2-(trifluoromethyl)pyridine (CAS 1804933-87-6)
- Triclopyricarb (CAS 902760-40-1)
- 4-(3-Carboxy-5-fluorophenyl)-2-fluorobenzoic acid (CAS 1261978-52-2)
- Neuropeptide Y (18-36) (CAS 114495-97-5)
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