2,3,5,6-Tetrafluoro-4-(trifluoromethyl)benzoic acid CAS 5216-22-8
| CAS No. | 5216-22-8 |
| Molecular Formula | C8HF7O2 |
| Molecular Weight | 262.08 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2,3,5,6-Tetrafluoro-4-(trifluoromethyl)benzoic acid.
2,3,5,6-Tetrafluoro-4-(trifluoromethyl)benzoic acid (CAS 5216-22-8), molecular formula C8HF7O2 and molecular weight 262.08 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, 2,3,5,6-Tetrafluoro-4-(trifluoromethyl)benzoic acid is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 262.08 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 2,3,5,6-Tetrafluoro-4-(trifluoromethyl)benzoic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8HF7O2 |
| Molecular Weight | 262.08 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | F-containing |
Related Tetrafluoro Standards
- 2,3,4,5-Tetrafluoro-6-methylbenzenesulfonyl chloride (CAS 2773501-44-1)
- 5-Methyl-2-(2,3,5,6-tetrafluoro-4-methylphenyl)-2,4-dihydro-3H-pyrazol-3-one (CAS 376593-04-3)
- 2,3,5,6-Tetrafluoro-4-trifluoromethyl-benzoylfluoride (CAS 117338-23-5)
- 4,5,6,7-Tetrafluoro-1-isopropyl-1H-indole-3-carbaldehyde (CAS 1350760-54-1)
- 2,3,5,6-Tetrafluoro-4-methoxybenzenesulfonamide (CAS 10459-98-0)
- 2,3,4,5-Tetrafluoro-6-methoxybenzenesulfonamide (CAS 2775301-25-0)
- 1,2,3,4-Tetrafluoro-9-methylacridine (CAS 33539-14-9)
- 2,2',6,6'-Tetrafluoro-[1,1'-biphenyl]-4,4'-diol (CAS 76463-15-5)
Recommended Standards
- 2-(6-fluorobenzofuran-7-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 2614262-12-1)
- 2,6-Dichloro-4-((trifluoromethyl)thio)aniline (CAS 99479-65-9)
- 1,1,1,3,5,5,5-Heptafluoropentane-2,2,4,4-tetraol (CAS 77953-71-0)
- 2-Amino-3-(3-bromo-4-fluorophenyl)propanoic acid (CAS 7771-11-1)
- 2-Bromo-1-(2-methoxypyridin-4-yl)ethanone (CAS 1187669-32-4)
- 4,5,6,7-Tetrahydro-2H-4,7-methanoisoindole (CAS 73696-20-5)
- 3,6-Dibromo-8-fluoroimidazo[1,2-a]pyridine (CAS 1260817-61-5)
- n-(2-Benzylphenyl)-2-chloropropanamide (CAS 94019-07-5)
- 1-(4-(Trifluoromethyl)phenyl)-1H-imidazole-4-carboxylic acid (CAS 445302-31-8)
- Bumetanide Impurity 74 (CAS CATO-C4X-198674)
- 2-Amino-2-(4-bromophenyl)acetonitrile (CAS 167024-66-0)
- (5-Methoxy-5-Oxopentyl) Triphenyl-Phosphonium Bromide (CAS 79837-79-9)
- Aztreonam Impurity 33 (CAS CATO-C4X-152233)
- Semaglutide impurity 267 (CAS CATO-C4X-2226267)
Why CATO?
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