Papaverine EP Impurity D (Papaveraldine) CAS 522-57-6
| CAS No. | 522-57-6 |
| Molecular Formula | C20H19NO5 |
| Molecular Weight | 353.37 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Papaverine EP Impurity D (Papaveraldine).
CATO supplies Papaverine EP Impurity D (Papaveraldine) (CAS 522-57-6), a pharmacopoeial impurity reference standard (molecular formula C20H19NO5, MW 353.37 g/mol) used for the identification and quantification of trace impurities in APIs.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, Papaverine EP Impurity D (Papaveraldine) is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 353.37 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H19NO5 |
| Molecular Weight | 353.37 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Papaverine Standards
- Papaverine EP Impurity B (Papaverinol) (CAS 482-76-8)
- Papaverine impurity 25 (CAS 33520-96-6)
- Papaverine EP Impurity F (CAS 139-76-4)
- Papaverine impurity 24 (CAS 33490-73-2)
- Papaverine Impurity 26 (CAS CATO-C4X-206726)
- Papaverine Impurity 39 (CAS 75608-42-3)
- Papaverine Impurity 40 (CAS 361389-65-3)
- Papaverine Impurity 42 (CAS CATO-C4X-206742)
Recommended Standards
- Indobufen Impurity 61 (CAS CATO-C4X-179261)
- Roxadustat Impurity 15 (CAS CATO-C4X-221315)
- Nafamostat impurity 100 (CAS CATO-C4X-1332100)
- Flubendazole EP Impurity G (CAS CATO-C4X-24387)
- Empagliflozin impurity 213 (CAS CATO-C4X-1065213)
- Phenylbutazone EP Impurity A (CAS 3583-64-0)
- Cetirizine impurity 31 (CAS CATO-C4X-158231)
- Ethyl 1-(2,5-dioxopyrrolidin-3-yl)piperidine-4-carboxylate (CAS 1455853-00-5)
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- rel-Methyl (2R,4R)-4-(2-chloro-4-nitrophenoxy)pyrrolidine-2-carboxylate (CAS 1217687-34-7)
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- 1-(2,4-Dihydroxyphenyl)-2-(isopropylthio)ethan-1-one (CAS 1179723-18-2)
- (Glu1)-Fibrinopeptide B (human) (CAS 103213-49-6)
Why CATO?
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