Ethambutol Hydrochloride EP Impurity D CAS 52399-93-6
| CAS No. | 52399-93-6 |
| Molecular Formula | C2H4Cl2 |
| Molecular Weight | 98.96 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ethambutol Hydrochloride EP Impurity D.
As a process- or degradation-related impurity, Ethambutol Hydrochloride EP Impurity D (CAS 52399-93-6, C2H4Cl2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C2H4Cl2, Ethambutol Hydrochloride EP Impurity D contains chlorine substitution; these features give the compound characteristic molecular-ion distribution patterns in mass spectrometry. The molecular weight of 98.96 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Ethambutol Hydrochloride EP Impurity D meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C2H4Cl2 |
| Molecular Weight | 98.96 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | Stable under recommended storage conditions |
| Degree of Unsaturation (DBE) | 0.0 |
| CAS Registry Year (est.) | 1971 |
| Halogen Content | Cl-containing |
Related Ethambutol Standards
- Ethambutol Hydrochloride EP Impurity A (CAS 96-20-8)
- Ethambutol Hydrochloride EP Impurity A (CAS 5856-63-3)
- Ethambutol EP Impurity C DiHCl (CAS 134566-79-3)
- Ethambutol Impurity 14 (CAS CATO-C4X-189414)
- Ethambutol Impurity 15 (CAS CATO-C4X-189415)
- Ethambutol EP Impurity B (2R,2’S-Ethambutol) DiHCl (CAS 32454-69-6)
- Ethambutol dihydrochloride (CAS 1070-11-7)
- Ethambutol-d4 Dihydrochloride (CAS 1129526-19-7)
Recommended Standards
- 1,1-Dichloroethylene-d2 (stabilized with hydroquinone) (CAS 22280-73-5)
- 1,2-Dichloroethane (CAS 107-06-2)
- 1,2-Dichloroethylene-d2 (cis/trans mixture) (CAS 15075-90-8)
- Dichloroethane (CAS 1300-21-6)
- Relebactam Impurity 115 (CAS 1174019-19-2)
- Treprostinil Impurity 10 (CAS 1911575-29-5)
- Loratadine Impurity 91 (CAS CATO-C4X-142691)
- 5-(4-Phenylbutyl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (CAS 21325-53-1)
- 1-Methyl-1H-pyrrolo[2,3-b]pyridin-4-amine (CAS 869335-48-8)
- Allyl 2-pyridyl ether (CAS 5831-77-6)
- 2',5'-Dimethoxy-[1,1'-biphenyl]-4-carbaldehyde (CAS 791839-61-7)
- (R)-2-(3-fluoro-4-methylphenyl)piperidine (CAS 1241680-10-3)
- 4-Chloro-2-methoxy-α-methyl-benzenemethanamine (CAS 138228-11-2)
- Semaglutide impurity 208 (CAS CATO-C4X-2226208)
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