1-(3-Chloro-4-methylphenyl)-3-methoxyurea CAS 52420-57-2
| CAS No. | 52420-57-2 |
| Molecular Formula | C9H11ClN2O2 |
| Molecular Weight | 214.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1-(3-Chloro-4-methylphenyl)-3-methoxyurea (C9H11ClN2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
1-(3-Chloro-4-methylphenyl)-3-methoxyurea (CAS 52420-57-2) is a high-purity analytical reference standard with the molecular formula C9H11ClN2O2 and a molecular weight of 214.65 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-(3-Chloro-4-methylphenyl)-3-methoxyurea meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H11ClN2O2 |
| Molecular Weight | 214.65 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1971 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
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Recommended Standards
- 1-(2-Chloro-5-nitrophenyl)-N,N-dimethylmethanamine (CAS 697305-62-7)
- 1-(5-Chloro-2,4-dimethoxyphenyl)ethan-1-one (CAS 54173-36-3)
- [3-Chloro-5-(oxetan-3-yloxy)-2-pyridyl]methanamine (CAS 2770348-08-6)
- 1-Chloro-9H-fluoren-9-one (CAS 36804-56-5)
- 5-Amino-3-fluoroquinoline (CAS 155014-05-4)
- (1,4-Dimethyl-1,2,3,4-tetrahydroquinoxalin-6-yl)methanamine (CAS 850375-15-4)
- 1-(2-(Trifluoromethyl)benzyl)-1h-imidazole-5-carboxylic acid (CAS 1439899-36-1)
- 5-Bromo-1-(piperidin-1-yl)isoquinoline (CAS 1330754-99-8)
- ZHC-116 Impurity 9 (CAS CATO-C4X-23889)
- 3,4-Dihydroxyquinoline-5-carboxylic acid (CAS 127980-50-1)
- Rocuronium Impurity 51 (CAS 103088-58-0)
- (4-Chlorophenyl)(piperidin-4-yl)methanamine (CAS 885595-64-2)
- Methyl(2S,6R)-6-methyl-4-oxopiperidine-2-carboxylate (CAS 2762829-80-9)
- Semaglutide impurity 54 (CAS CATO-C4X-222654)
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