Citicoline Impurity 6 CAS 52448-10-9
| CAS No. | 52448-10-9 |
| Molecular Formula | C10H16N3O8P |
| Molecular Weight | 337.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 337.22 g/mol gives Citicoline Impurity 6 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Citicoline Impurity 6 (CAS 52448-10-9) is a certified pharmaceutical impurity reference standard with the molecular formula C10H16N3O8P and a molecular weight of 337.22 g/mol.
The molecular framework of Citicoline Impurity 6 (C10H16N3O8P) is characterized by a carbohydrate-derived structure, an amide group, a phosphate ester group. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H16N3O8P |
| Molecular Weight | 337.22 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1971 |
| Nitrogen Atoms | 3 |
Related Citicoline Standards
- Citicoline Impurity 8 (CAS 3036-18-8)
- Citicoline (CAS 987-78-0)
- Citicoline Impurity 7 (CAS 99492-83-8)
- Citicoline Impurity 109 (CAS 4421-58-3)
- Citicoline Impurity 18 (CAS CATO-C4X-220318)
- Citicoline Impurity 16 (CAS CATO-C4X-220316)
- Citicoline Impurity 17 (CAS CATO-C4X-220317)
- Citicoline Impurity D Morpholidate (CAS 76742-18-2)
Recommended Standards
- N-(2-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)benzamide (CAS 2095280-78-5)
- 1-(2,4-Difluorophenyl)-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid (CAS 103995-01-3)
- 5-Methylcytidylic acid (CAS 3590-36-1)
- 2-(3-Bromophenyl)-N-methyl-N-(thiazol-2-yl)cyclopropane-1-carboxamide (CAS 1311870-36-6)
- Velpatasvir Impurity 1 (CAS CATO-C4X-28941)
- Linagliptin Impurity 38 (CAS 1803079-49-3)
- Bosutinib Impurity 20 (CAS CATO-C4X-184720)
- 4-Methyl-N-((4-(thiophen-2-yl)tetrahydro-2H-pyran-4-yl)methyl)benzenesulfonamide (CAS 1203192-01-1)
- 2,2-diethoxy-2-(pyridin-4-yl)ethan-1-amine (CAS 74209-44-2)
- 1-((5-Cyclopropyl-1,2,4-oxadiazol-3-yl)methyl)piperidin-4-amine (CAS 1247617-23-7)
- 3-(4-Bromophenyl)-6-methylpyridazine (CAS 100677-88-1)
- Prop-2-yn-1-yl 5-(4-cyanophenyl)furan-2-carboxylate (CAS 1706461-74-6)
- Norepinephrine Impurity 117 (CAS CATO-C4X-1514117)
- D-Lys20-Tirzepatide (CAS CATO-CPTD788914)
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