Citicoline Impurity 8 CAS 3036-18-8
| CAS No. | 3036-18-8 |
| Molecular Formula | C11H20N4O11P2 |
| Molecular Weight | 446.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Citicoline Impurity 8 (CAS 3036-18-8) is a certified pharmaceutical impurity reference standard with the molecular formula C11H20N4O11P2 and a molecular weight of 446.24 g/mol.
Owing to a carbohydrate-derived structure, an amide group, a phosphate ester group, Citicoline Impurity 8 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 446.24 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H20N4O11P2 |
| Molecular Weight | 446.24 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 4 |
Related Citicoline Standards
- Citicoline (CAS 987-78-0)
- Citicoline Impurity 7 (CAS 99492-83-8)
- Citicoline Impurity 109 (CAS 4421-58-3)
- Citicoline Impurity 18 (CAS CATO-C4X-220318)
- Citicoline Impurity 6 (CAS 52448-10-9)
- Citicoline Impurity 16 (CAS CATO-C4X-220316)
- Citicoline Impurity 17 (CAS CATO-C4X-220317)
- Citicoline Impurity D Morpholidate (CAS 76742-18-2)
Recommended Standards
- N,N'-(Ethane-1,2-diyl)bis(3-chloropropanamide) (CAS 31481-06-8)
- Fluralaner Impurity N3 (CAS 864725-61-1)
- Ethyl 1-(4-(4-bromophenyl)thiazol-2-yl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate (CAS 955976-70-2)
- Cytidine Diphosphate Ethanolamine (CDPEA) (CAS 3038-18-8)
- Dolutegravir Impurity 25 (CAS 2730133-58-9)
- Ixazomib Impurity 43 (CAS CATO-C4X-126743)
- Betamethasone Impurity 119 (CAS CATO-C4X-1437119)
- N-(3-Cyano-4,5-dimethylthiophen-2-yl)-2-(ethylthio)benzamide (CAS 886918-82-7)
- 2-Fluoro-2'-O-methyl adenosine (CAS 116525-89-4)
- 2-Isopropoxy-4-nitroaniline (CAS 105168-93-2)
- Isoflucypram (CAS 1255734-28-1)
- 2,3,5,6-Tetrafluoro-4-vinylphenol (CAS 385422-30-0)
- Bumetanide Impurity 61 (CAS 94610-14-7)
- Serpent Peptide 2AcOH (CAS 823202-99-9(free base))
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