Amiodarone EP Impurity E CAS 52490-15-0
| CAS No. | 52490-15-0 |
| Molecular Formula | C19H18O3 |
| Molecular Weight | 294.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Amiodarone EP Impurity E.
Amiodarone EP Impurity E (CAS 52490-15-0) is a certified pharmaceutical impurity reference standard with the molecular formula C19H18O3 and a molecular weight of 294.34 g/mol.
Owing to a steroid core, a hydroxyl group, an ether linkage, Amiodarone EP Impurity E is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 294.34 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Amiodarone EP Impurity E meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C19H18O3 |
| Molecular Weight | 294.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1971 |
Related Amiodarone Standards
- Amiodarone Impurity 25 (CAS CATO-C4X-142525)
- Amiodarone Impurity 27 (CAS CATO-C4X-142527)
- Amiodarone Impurity 13 (CAS 83790-87-8)
- Amiodarone Impurity 24 (CAS CATO-C4X-142524)
- Amiodarone Impurity 26 (CAS CATO-C4X-142526)
- Amiodarone Impurity 50 (CAS CATO-C4X-142550)
- Amiodarone Impurity 38 (CAS 138320-26-0)
- Amiodarone Impurity 39 (CAS 138320-27-1)
Recommended Standards
- Iomeprol Impurity 13 (CAS CATO-C4X-182013)
- 1,3-Benzenedisulfonic acid, diethyl ester (CAS 34577-48-5)
- 898758-32-2 Ethyl 6-(2,5-dimethoxyphenyl)-6-oxohexanoate DTXSID40645818 (CAS 898758-32-2)
- Mono(2-ethyl-6-hydroxyhexyl) Phthalate (CAS 82975-96-0)
- Palbociclib Impurity 120 (CAS CATO-C4X-1125120)
- Vonoprazan Impurity 64 (CAS 928324-73-6)
- Terazosin EP Impurity B (CAS 1177261-73-2)
- 2,6-Diphenylpiperidin-4-one (CAS 5554-55-2)
- 2-((((1-(2,2,2-Trifluoroethyl)-1H-pyrazol-3-yl)methyl)amino)methyl)benzoic acid hydrochloride (CAS 1855945-37-7)
- 3-Chloro-2-[(Z)-2-[(3E)-3-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]hydrazin-1-ylidene}butan-2-ylidene]hydrazin-1-yl]-5-(trifluoromethyl)pyridine (CAS 338758-98-8)
- Undecanoic acid, 11-amino-, homopolymer (CAS 25587-80-8)
- 1-Chloro-4-(1,1,2,2-tetrafluoroethoxy)benzene (CAS 75820-58-5)
- 5-Chloro-2H-chromen-2-one (CAS 38169-98-1)
- Insulin B (22-25) (CAS 34367-73-2)
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