Benzylpenicillin Impurity 74 CAS 5259-87-0
| CAS No. | 5259-87-0 |
| Molecular Formula | C11H13NO3 |
| Molecular Weight | 207.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Benzylpenicillin Impurity 74.
As a process- or degradation-related impurity, Benzylpenicillin Impurity 74 (CAS 5259-87-0, C11H13NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Benzylpenicillin Impurity 74 (C11H13NO3) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 207.23 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Benzylpenicillin Impurity 74 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H13NO3 |
| Molecular Weight | 207.23 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 1 |
Related Benzylpenicillin Standards
- Benzylpenicillin Impurity 34 (CAS 56609-07-5)
- Benzylpenicillin CP Impurity H (CAS 500-98-1)
- Benzylpenicillin Impurity N1 (CAS 64950-14-7)
- Benzylpenicillin Impurity 56 (CAS CATO-C4X-189956)
- Benzylpenicillin CP Impurity G (CAS CATO-C4X-18997)
- Benzylpenicillin Impurity 77 (CAS CATO-C4X-189977)
- Benzylpenicillin Impurity 55 (CAS 64527-07-7)
- Benzylpenicillin (Benzathine) Tetrahydrate EP Impurity A (CAS 4152-09-4)
Recommended Standards
- Etomidate Impurity 74 (CAS CATO-C4X-188474)
- Revefenacin impurity 97 (CAS 774238-89-0)
- Etomidate Impurity 15 (CAS CATO-C4X-188415)
- Thiotepa Impurity 2 (CAS 121258-29-5)
- Phenylephrine Impurity 12 (CAS CATO-C4X-146712)
- Hydroxocobalamin Hydrochloride( Cyanocobalamin EP Impurity H HCl） (CAS 58288-50-9)
- Benzylpenicillin CP Impurity J (CAS CATO-C4X-189910)
- Tiospirone HCl (CAS 87691-92-7)
- Methyl 3-amino-4-fluorobenzo[b]thiophene-2-carboxylate (CAS 144899-95-6)
- (5-Bromo-2-chloropyridin-4-yl)(pyrrolidin-1-yl)methanone (CAS 1875545-42-8)
- (S)-7a-(aminomethyl)-2,2-dimethylhexahydro-3H-pyrrolizin-3-one (CAS 1788873-60-8)
- 2-(Morpholin-4-yl)-N-[4-({4-[2-(morpholin-4-yl)acetamido]phenyl}methyl)phenyl]acetamide (CAS 306732-42-3)
- 2,6-Bis(diphenylphosphino)pyridine (CAS 64741-27-1)
- Semaglutide impurity 193 (CAS CATO-C4X-2226193)
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