Hydroxocobalamin Hydrochloride( Cyanocobalamin EP Impurity H HCl） CAS 58288-50-9
| CAS No. | 58288-50-9 |
| Molecular Formula | C62H89CoN13O15P |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 1382.84 g/mol gives Hydroxocobalamin Hydrochloride( Cyanocobalamin EP Impurity H HCl） distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Hydroxocobalamin Hydrochloride( Cyanocobalamin EP Impurity H HCl） (CAS 58288-50-9, C62H89CoN13O15PHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Hydroxocobalamin Hydrochloride( Cyanocobalamin EP Impurity H HCl） (C62H89CoN13O15PHCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Hydroxocobalamin Hydrochloride( Cyanocobalamin EP Impurity H HCl） meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C62H89CoN13O15P HCl |
| Molecular Weight | 1382.84 g/mol |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 24.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1973 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 13 |
Related Hydroxocobalamin Standards
Recommended Standards
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- Nacubactam Impurity 1 (CAS CATO-C4X-33001)
- (2-Bromo-6-methoxypyridin-4-yl)methanol (CAS 1804846-68-1)
- 2-(Difluoromethyl)-4-methylpyridine-3-acetic acid (CAS 1805280-35-6)
- 2-(1-methyl-1H-pyrrol-3-yl)acetic acid (CAS 915919-88-9)
- 3,4-Difluoro-5-nitrobenzenesulfonamide (CAS 1803826-57-4)
- 4-Chloro-3-(difluoromethyl)-2,6-difluoropyridine (CAS 1806007-91-9)
- 3-Bromo-1-(4-chlorophenyl)-1H-pyrrole-2,5-dione (CAS 500862-82-8)
- Tau Peptide (268-282) trifluoroacetate salt (CAS 330456-37-6)
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