5-(Bromomethyl)-3-(4-fluorophenyl)isoxazole CAS 5262-25-9
| CAS No. | 5262-25-9 |
| Molecular Formula | C10H7BrFNO |
| Molecular Weight | 256.07 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-(Bromomethyl)-3-(4-fluorophenyl)isoxazole.
5-(Bromomethyl)-3-(4-fluorophenyl)isoxazole (CAS 5262-25-9) is a high-purity analytical reference standard with the molecular formula C10H7BrFNO and a molecular weight of 256.07 g/mol.
The molecular framework of 5-(Bromomethyl)-3-(4-fluorophenyl)isoxazole (C10H7BrFNO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-(Bromomethyl)-3-(4-fluorophenyl)isoxazole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H7BrFNO |
| Molecular Weight | 256.07 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
Related Bromomethyl Standards
- 2-[4-(bromomethyl)-3-fluorophenyl]-1,3-oxazole (CAS 1245651-29-9)
- 4-(Bromomethyl)-8-fluoroquinolin-2-ol (CAS 176912-29-1)
- 2-(Bromomethyl)-5-(4-fluorophenyl)-1,3-oxazole (CAS 855991-59-2)
- 4-(Bromomethyl)-6-nitro-1H-benzo[d]imidazole (CAS 1804144-52-2)
- 2-(Bromomethyl)benzo[d]oxazole-5-carboxylic acid (CAS 1804145-45-6)
- 2-(Bromomethyl)benzo[d]oxazole-6-carboxylic acid (CAS 1806555-96-3)
- 2-(Bromomethyl)-4-nitrobenzofuran (CAS 1936370-15-8)
- 7-(Bromomethyl)-5-nitrobenzofuran (CAS 856678-94-9)
Recommended Standards
- 5-(5-Bromo-2-fluoro-3-methylphenyl)oxazole (CAS 2364584-92-7)
- 5'-Bromo-4'-fluorospiro[cyclopropane-1,3'-indolin]-2'-one (CAS 913720-17-9)
- 5-(4-Bromo-2-fluoro-5-methylphenyl)oxazole (CAS 2364585-02-2)
- 5-Bromo-7-fluorochromane-8-carbonitrile (CAS 2055392-62-4)
- 4-ethyl-3,5-dimethyl-1H-pyrrole-2-carbaldehyde (CAS 6250-80-2)
- 4,5,6,7-Tetrahydro-2H-4,7-methanoisoindole (CAS 73696-20-5)
- Ethyl (1S,2R)-2-amino-5,5-difluorocyclohexane-1-carboxylate (CAS 1092728-64-7)
- 77232-13-4 2-(p-Tolyl)pyrimidine MFCD08701658 (CAS 77232-13-4)
- 1-(m-Tolyl)-5-(trifluoromethyl)pyrazole-4-carboxylic Acid (CAS 786726-99-6)
- 4-[(1-Isocyanocyclopropyl)sulfonyl]toluene (CAS 63805-77-6)
- Epirubicin hydrochloride (CAS 56390-09-1)
- 7-Methyl-2-naphthonitrile (CAS 38879-96-8)
- 3-Chloro-2-nitrobenzenesulfonyl chloride (CAS 78846-40-9)
- Pancreatic Polypeptide (bovine) (CAS 179986-89-1)
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