Hydroxymethyl Coumarin Impurity 7 CAS 52751-48-1
| CAS No. | 52751-48-1 |
| Molecular Formula | C14H12O5 |
| Molecular Weight | 260.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Hydroxymethyl Coumarin Impurity 7 (C14H12O5) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Hydroxymethyl Coumarin Impurity 7 (CAS 52751-48-1, C14H12O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Hydroxymethyl Coumarin Impurity 7 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H12O5 |
| Molecular Weight | 260.24 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1972 |
Related Hydroxymethyl Standards
- 3-(5-(Hydroxymethyl)benzo[d]isoxazol-3-yl)piperidine-2,6-dione (CAS 2623102-50-9)
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- Methyl 5-(hydroxymethyl)-1,2-dimethyl-4-phenyl-1H-pyrrole-3-carboxylate (CAS 117663-40-8)
- (S)-4-(2-(Hydroxymethyl)pyrrolidin-1-yl)-2-methylquinazolin-7-ol (CAS 646450-67-1)
- methyl 2-(hydroxymethyl)-1-(2-methoxyethyl)imidazo[1,2-b]pyrazole-6-carboxylate (CAS 2756784-41-3)
- 4-(Hydroxymethyl)-1-(3-(trifluoromethyl)phenyl)pyrrolidin-2-one (CAS 1512199-31-3)
- 2-(Hydroxymethyl)-5-[(4-methoxybenzyl)oxy]pyridin-4(1H)-one (CAS 118679-90-6)
- 2-((5-(Hydroxymethyl)tetrahydrofuran-2-yl)methyl)isoindoline-1,3-dione (CAS 2247618-96-6)
Recommended Standards
- Cytarabine Impurity 10 (CAS CATO-C4X-200510)
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- Norepinephrine Impurity 50 (CAS 100622-09-1)
- Methyl 1-((2-formylphenoxy)methyl)-1H-pyrazole-3-carboxylate (CAS 1005566-45-9)
- Mirogabalin Impurity 94 (CAS CATO-C4X-292494)
- Sildenafil Impurity 28 (CAS 139756-26-6)
- Clofarabine Impurity 16 (CAS CATO-C4X-159316)
- Ethyl 5-amino-1-(2-chlorophenyl)-1H-pyrazole-3-carboxylate (CAS 866838-00-8)
- 2-Iodo-3-methoxynaphthalene (CAS 795278-91-0)
- 3-(2-Methoxyphenyl)-1-(piperidin-4-yl)urea (CAS 503464-79-7)
- 114772-35-9 4'-Methyl[1,1'-biphenyl]-2-carbonyl chloride DTXSID50560149 (CAS 114772-35-9)
- 2-Bromo-1-(4-bromo-3-methoxyphenyl)ethanone (CAS 1427431-26-2)
- 5-(Ethylamino)pyrazine-2-carbonitrile (CAS 1409987-87-6)
- ([D?]Val?·1?)-C-Peptide (human) (CAS 1802078-41-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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