Fenfluramine Impurity 1 CAS 52777-74-9
| CAS No. | 52777-74-9 |
| Molecular Formula | C13H18F3N |
| Molecular Weight | 245.28 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Fenfluramine Impurity 1.
Fenfluramine Impurity 1 (CAS 52777-74-9) is a certified pharmaceutical impurity reference standard with the molecular formula C13H18F3N and a molecular weight of 245.28 g/mol.
Structurally, Fenfluramine Impurity 1 (C13H18F3N) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 245.28 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H18F3N |
| Molecular Weight | 245.28 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1972 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Fenfluramine Standards
- DL-Fenfluramine (CAS 458-24-2)
- Fenfluramine Impurity 1 (CAS 19023-40-6)
- Fenfluramine Impurity 8 (CAS 621-45-4)
- Nor-Fenfluramine (CAS 1886-26-6)
- Fenfluramine Impurity 2 (CAS 21235-67-6)
- Fenfluramine Impurity 3 (CAS 713-45-1)
- Fenfluramine Impurity 4 (CAS 21906-39-8)
- Fenfluramine hydrochloride (CAS 16105-77-4)
Recommended Standards
- Ethyl 5-Amino-1-benzylimidazole-4-carboxylate (CAS 68462-61-3)
- L-Histidine Benzyl Ester (CAS 46921-20-4)
- ethyl 5-amino-1-benzyl-1H-pyrazole-4-carboxylate (CAS 19867-62-0)
- Methyl 5-cyano-2-methyl-6-(pyrrolidin-1-yl)nicotinate (CAS 303146-75-0)
- Apremilast impurity 17 (CAS CATO-C4X-100917)
- Glycyrrhizic Acid Impurity 27 (CAS CATO-C4X-253727)
- Dopamine EP Impurity B (CAS 554-52-9)
- trans-1-amino-3-methyl-cyclobutanecarboxylic acid (CAS 184103-74-0)
- 1,4-Dithia-7-azaspiro[4.4]nonane (CAS 1003-80-1)
- Cefazolin-13C2-15N (CAS 2101505-58-0)
- 4-Carbamimidoylbenzoyl chloride (CAS 138109-35-0)
- 1-(4-Chlorophenyl)-3-(ethoxycarbonyl)-4,5-dihydro-1h-pyrazole-5-carboxylic acid (CAS 1264043-89-1)
- 6-Bromo-4-(difluoromethyl)-5-(trifluoromethyl)nicotinaldehyde (CAS 1804493-88-6)
- Eledoisin Related Peptide (CAS 2990-43-4)
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