Flurbiprofen Impurity 16 CAS 52807-12-2
| CAS No. | 52807-12-2 |
| Molecular Formula | C15H13FO3 |
| Molecular Weight | 260.26 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Flurbiprofen Impurity 16 (CAS 52807-12-2, C15H13FO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Flurbiprofen Impurity 16 (C15H13FO3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H13FO3 |
| Molecular Weight | 260.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1972 |
| Halogen Content | F-containing |
Related Flurbiprofen Standards
- Flurbiprofen EP Impurity C (CAS 61466-95-3)
- Flurbiprofen Impurity 24 (CAS 66202-86-6)
- Flurbiprofen Impurity 164 (CAS 52806-83-4)
- Flurbiprofen Impurity 171 (CAS CATO-C4X-1444171)
- Flurbiprofen impurity 123 (CAS CATO-C4X-1444123)
- Flurbiprofen Impurity 59 (CAS CATO-C4X-144459)
- Flurbiprofen Impurity 73 (CAS CATO-C4X-144473)
- Flurbiprofen Impurity 88 (CAS 1915720-16-9)
Recommended Standards
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- Propofol Impurity 50 (CAS CATO-C4X-147350)
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- Kukoamine Impurity 6 (CAS CATO-C4X-22966)
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- Ethyl 5-(pyridin-4-yl)-1h-pyrazole-4-carboxylate (CAS 911462-21-0)
- (Leu31,Pro3?)-Neuropeptide Y (human, rat) trifluoroacetate salt (CAS 132699-73-1)
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