Flurbiprofen Impurity 24 CAS 66202-86-6
| CAS No. | 66202-86-6 |
| Molecular Formula | C16H15FO2 |
| Molecular Weight | 258.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Flurbiprofen Impurity 24.
Flurbiprofen Impurity 24 (CAS 66202-86-6) is a certified pharmaceutical impurity reference standard with the molecular formula C16H15FO2 and a molecular weight of 258.29 g/mol.
The molecular framework of Flurbiprofen Impurity 24 (C16H15FO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H15FO2 |
| Molecular Weight | 258.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1975 |
| Halogen Content | F-containing |
Related Flurbiprofen Standards
- Flurbiprofen Impurity 164 (CAS 52806-83-4)
- Flurbiprofen Impurity 171 (CAS CATO-C4X-1444171)
- Flurbiprofen Impurity 16 (CAS 52807-12-2)
- Flurbiprofen EP Impurity C (CAS 61466-95-3)
- Flurbiprofen impurity 123 (CAS CATO-C4X-1444123)
- Flurbiprofen Impurity 59 (CAS CATO-C4X-144459)
- Flurbiprofen Impurity 73 (CAS CATO-C4X-144473)
- Flurbiprofen Impurity 27 (CAS 136649-30-4)
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- Isavuconazole Impurity 19 (CAS CATO-C4X-123619)
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- Carbetocin Impurity 37 (CAS CATO-C4X-191137)
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- b-Hydrocodol (CAS 795-38-0)
- Trimethylamine-¹⁵N (CAS 25756-36-9)
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