Memantine Impurity 43 CAS 53343-18-3
| CAS No. | 53343-18-3 |
| Molecular Formula | C12H15F3O2 |
| Molecular Weight | 248.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 248.24 g/mol gives Memantine Impurity 43 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Memantine Impurity 43 (CAS 53343-18-3), a pharmacopoeial impurity reference standard (molecular formula C12H15F3O2, MW 248.24 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Memantine Impurity 43 (C12H15F3O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 248.24 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Memantine Impurity 43 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H15F3O2 |
| Molecular Weight | 248.24 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1972 |
| Halogen Content | F-containing |
Related Memantine Standards
- Memantine Impurity 26 (CAS 878-61-5)
- Memantine Related Compound D (CAS 941-37-7)
- Memantine Impurity 64 (CAS 2123482-13-1)
- Memantine Glycine (CAS 1340545-88-1)
- Memantine Impurity N2 (CAS 15210-64-7)
- Memantine Impurity 34 (CAS 702-77-2)
- Memantine Impurity 21 (CAS CATO-C4X-105821)
- Memantine impurity 55 (CAS CATO-C4X-105855)
Recommended Standards
- Topiroxostat Impurity 37 (CAS 2044706-68-3)
- Tegoprazan impurity 37 (CAS CATO-C4X-229737)
- Topiroxostat Impurity 36 (CAS CATO-C4X-105536)
- Indolo[2,1-b]quinazoline-6,12-dione (CAS 13220-57-0)
- Vonoprazan Impurity 233 (CAS CATO-C4X-1020233)
- Cytarabine EP Impurity F (CAS 32830-01-6)
- Doxorubicin Impurity 14 (CAS CATO-C4X-203314)
- 6-Chloro-2-phenylquinazoline (CAS 58058-53-0)
- Tert-butyl (2S,3S)-3-(3-fluorophenyl)aziridine-2-carboxylate (CAS 1980007-29-1)
- Methyl 5-amino-1-methyl-1H-pyrrole-3-carboxylate (CAS 1220040-22-1)
- 1-(Sec-butyl)-1H-pyrazol-5-amine (CAS 3524-19-4)
- N-(2-Phenylethyl)-1,3-benzothiazol-2-amine (CAS 439215-15-3)
- 1-(2-Methoxyphenyl)-1H-imidazole (CAS 10040-93-4)
- D-Pro38-Tirzepatide (CAS CATO-CPTD788901)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com