Memantine Impurity 64 CAS 2123482-13-1
| CAS No. | 2123482-13-1 |
| Molecular Formula | C12H20BrN |
| Molecular Weight | 258.20 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Memantine Impurity 64.
As a process- or degradation-related impurity, Memantine Impurity 64 (CAS 2123482-13-1, C12H20BrN) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Memantine Impurity 64 (C12H20BrN) is characterized by a nitrile group, bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H20BrN |
| Molecular Weight | 258.20 g/mol |
| Purity | ≥95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1997 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 1 |
Related Memantine Standards
- Memantine Impurity 43 (CAS 53343-18-3)
- Memantine Impurity 26 (CAS 878-61-5)
- Memantine Related Compound D (CAS 941-37-7)
- Memantine Impurity 62 (CAS 14931-70-5)
- Memantine Glycine (CAS 1340545-88-1)
- Memantine Impurity N2 (CAS 15210-64-7)
- Memantine impurity 58 (CAS 49764-18-3)
- Memantine Impurity 34 (CAS 702-77-2)
Recommended Standards
- N1-(4-(Trifluoromethyl)phenyl)fumaramide (CAS 367908-32-5)
- 5-(4-fluorophenyl)[1,2,4]triazolo[1,5-a]pyrimidine-7-carboxylic acid (CAS 1018143-24-2)
- N1-(3-(Trifluoromethyl)phenyl)fumaramide (CAS 301683-23-8)
- 3-(6-Fluoropyridin-2-yl)-5-nitro-1H-indazole (CAS 1356087-86-9)
- Rapamycin Impurity 11 (CAS 159351-88-9)
- Cefditoren Impurity 53 (CAS CATO-C4X-135853)
- Tenofovir Disoproxil Impurity 46 (CAS CATO-C4X-107646)
- Ethyl (6-methylpyridin-2-yl)carbamate (CAS 103796-10-7)
- 3-(Methoxymethyl)benzene-1,2-diamine (CAS 916325-86-5)
- (s)-2-piperidinone-6-carboxylic acid (s)-6-oxo-2-piperidinecarboxylic acid (s)-6-oxo-piperidine-2-carboxylic acid 34622-39-4 L-6-Oxo-pipecolinic acid (CAS 34622-39-4)
- 2-chloro-5-nitro-pyrazine (CAS 87885-45-8)
- Ethyl 5-Bromo-1-methylpyrazole-4-carboxylate (CAS 105486-72-4)
- 4,5,6,7-Tetrahydropyrazolo[1,5-a]pyrazine-3-carbonitrile (CAS 2092006-85-2)
- Q-Peptide trifluoroacetate salt (CAS 1361235-89-3)
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