Benzocaine impurity 32 CAS 5338-44-3
| CAS No. | 5338-44-3 |
| Molecular Formula | C11H13NO3 |
| Molecular Weight | 207.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Benzocaine impurity 32.
Benzocaine impurity 32 (CAS 5338-44-3) is a certified pharmaceutical impurity reference standard with the molecular formula C11H13NO3 and a molecular weight of 207.23 g/mol.
The molecular framework of Benzocaine impurity 32 (C11H13NO3) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Benzocaine impurity 32 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H13NO3 |
| Molecular Weight | 207.23 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Nitrogen Atoms | 1 |
Related Benzocaine Standards
- Benzocaine-13C6 (CAS 1391054-61-7)
- Benzocaine EP Impurity D (CAS 1333-08-0)
- Benzocaine EP Impurity C (CAS 582-33-2)
- Benzocaine EP Impurity H (CAS 619-45-4)
- Benzocaine EP Impurity G (CAS 150-13-0)
- Benzocaine EP Impurity A (CAS 623-04-1)
- Benzocaine EP Impurity F (CAS 1877-77-6)
- Benzocaine Impurity 31 (CAS 71134-95-7)
Recommended Standards
- 5-(4-nitrosopiperazin-1-yl)pyridin-2-amine (CAS CATO-C4X-249316)
- N-Isopropylnoradrenochrome (CAS 3736-31-0)
- Thiotepa Impurity 2 (CAS 121258-29-5)
- Isoprenaline Impurity 17 (CAS CATO-C4X-277517)
- N-Nitroso Resmetirom impurity 142 (CAS CATO-C4X-2912142)
- (E,E)-Ceftizoxime Impurity 67 (CAS CATO-C4X-179367)
- Estazolam Impurity 3 (CAS 10352-28-0)
- Ethyl 2-carbamoylisonicotinate (CAS 166766-77-4)
- 2-((5-(1-((4-Bromophenyl)amino)ethyl)-4-methyl-4H-1,2,4-triazol-3-yl)thio)acetohydrazide (CAS 1306738-58-8)
- Fmoc-Tyr(Et)-OH (CAS 119894-20-1)
- 3-Nitro-4-(trifluoromethyl)phenol (CAS 25889-36-5)
- Perindopril Impurity 69 (CAS 145513-92-4 (free base))
- Tofacitinib Impurity 56 (CAS 923036-30-0)
- CGMP Dependent Kinase Inhibitor Peptide (CAS 82801-73-8)
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