2-Amino-3-(2-chloroethyl)-1,3,2-oxazaphosphinane 2-oxide CAS 53459-55-5
| CAS No. | 53459-55-5 |
| Molecular Formula | C5H12ClN2O2P |
| Molecular Weight | 198.59 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-Amino-3-(2-chloroethyl)-1,3,2-oxazaphosphinane 2-oxide (CAS 53459-55-5), molecular formula C5H12ClN2O2P and molecular weight 198.59 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-Amino-3-(2-chloroethyl)-1,3,2-oxazaphosphinane 2-oxide (C5H12ClN2O2P) is characterized by an amide group, organophosphorus functionality, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 2-Amino-3-(2-chloroethyl)-1,3,2-oxazaphosphinane 2-oxide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H12ClN2O2P |
| Molecular Weight | 198.59 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 0.5 |
| CAS Registry Year (est.) | 1972 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Amino Standards
- 8-Amino-6-chloro-4h-benzo[1,4]oxazin-3-one (CAS 1042973-67-0)
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