2-Methoxypyridine-3-carbonyl chloride CAS 53750-65-5
| CAS No. | 53750-65-5 |
| Molecular Formula | C7H6ClNO2 |
| Molecular Weight | 171.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 2-Methoxypyridine-3-carbonyl chloride (CAS 53750-65-5), a certified reference material (molecular formula C7H6ClNO2, MW 171.58 g/mol) for analytical method development and quality control.
The molecular framework of 2-Methoxypyridine-3-carbonyl chloride (C7H6ClNO2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H6ClNO2 |
| Molecular Weight | 171.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1972 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Methoxypyridine Standards
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- 6-Methoxypyridine-3-carbothioanide (CAS 175277-49-3)
Recommended Standards
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- 3-Amino-5-chlorobenzoic Acid (CAS 21961-30-8)
- Methyl (2S,4S)-4-[2-nitro-4-(trifluoromethyl)-phenoxy]-2-pyrrolidinecarboxylate hydrochloride (CAS 1354486-89-7)
- 2-(4-Fluoropiperidin-4-yl)pyridine (CAS 853576-43-9)
- 951891-13-7 2-Chloro-3-(2,5-dimethoxyphenyl)-1-propene MFCD09801181 (CAS 951891-13-7)
- 1138445-85-8 2-Bromo-N-{2-[(4-methyl-1-piperidinyl)carbonyl]-phenyl}acetamide 9151AC C15H19BrN2O2 (CAS 1138445-85-8)
- 3-(3-(Tetrahydrofuran-2-yl)-1,2,4-oxadiazol-5-yl)propanoic acid (CAS 1483807-06-2)
- rel-tert-Butyl (3R,4S)-3-ethyl-4-hydroxypyrrolidine-1-carboxylate (CAS 1228880-43-0)
- 5-Bromoisochroman-4-one (CAS 1260803-28-8)
- (3S,4S)-tert-Butyl 3-allyl-4-hydroxypyrrolidine-1-carboxylate (CAS 2165370-65-8)
- 3,3-Difluoro-3-(4-fluorophenyl)-2-oxopropionic acid monohydrate (CAS 1210332-23-2)
- Des-[Gly]31-Semaglutide (CAS CATO-C4X-2226156)
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