Sorafenib Impurity 46 CAS 53750-66-6
| CAS No. | 53750-66-6 |
| Molecular Formula | C6H3Cl2NO |
| Molecular Weight | 176.00 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Sorafenib Impurity 46 (CAS 53750-66-6) is a certified pharmaceutical impurity reference standard with the molecular formula C6H3Cl2NO and a molecular weight of 176.00 g/mol.
Sorafenib Impurity 46 (C6H3Cl2NO) contains an amide group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H3Cl2NO |
| Molecular Weight | 176.00 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1972 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Sorafenib Standards
- Sorafenib Impurity 54 (CAS 67455-41-8)
- Sorafenib Impurity 67 (CAS 131418-11-6)
- Sorafenib Impurity 14 (CAS 845306-04-9)
- Sorafenib Impurity 47 (CAS 220000-87-3)
- Sorafenib Impurity 51 (CAS 52943-20-1)
- Sorafenib Impurity 50 (CAS 1065074-98-7)
- Sorafenib Impurity 20 (CAS 329-01-1)
- Sorafenib Impurity 48 (CAS 5470-22-4)
Recommended Standards
- Methylenediphosphonic Acid (CAS 1984-15-2)
- Thiotepa Impurity 13 (CAS 1879073-27-4)
- 2-Chloropyridine-4-carbonyl chloride 65287-34-5 cis-1-Acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine (CAS 65287-34-5)
- 5-Bromo-1,4-dimethyl-1H-1,2,3-triazole (CAS 1040275-55-5)
- Regorafenib Impurity 14 (CAS 835621-12-0)
- Neratinib Impurity 44 (CAS 1222172-50-0)
- Aztreonam impurity 55 (CAS CATO-C4X-152255)
- (1R,4r)-4-(5-bromo-2-(butylamino)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexan-1-ol (CAS 2306252-86-6)
- (s)-2-Amino-2-(2-bromo-5-fluorophenyl)ethan-1-ol (CAS 1213371-91-5)
- 2-((3-Methyl-4-nitroisoxazol-5-yl)amino)-2-oxoethyl acetate (CAS 41230-60-8)
- Benzopyrene Related Compound 3 (Benzo[a]pyrene-7, 8-Diol) (CAS 57303-99-8)
- 5-n,5-n-Diethylisoquinoline-5,8-diamine (CAS 1154275-79-2)
- (3aR,4R,5R,6aS)-2-Oxo-4-((E)-3-oxooct-1-en-1-yl)hexahydro-2H-cyclopenta[b]furan-5-yl benzoate (CAS 40834-86-4)
- ([13C6]Leu14)-Glucagon (1-29) (human, rat, porcine) trifluoroacetate salt (CAS 1802078-39-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com