Nintedanib Impurity 48 DiHCl CAS 5395-70-0
| CAS No. | 5395-70-0 |
| Molecular Formula | C7H10N2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Nintedanib Impurity 48 DiHCl (CAS 5395-70-0) is a certified pharmaceutical impurity reference standard with the molecular formula C7H10N2HCl and a molecular weight of 158.63 g/mol.
The molecular framework of Nintedanib Impurity 48 DiHCl (C7H10N2HCl) is characterized by a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO manufactures Nintedanib Impurity 48 DiHCl under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C7H10N2 2*HCl |
| Molecular Weight | 158.63 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Nintedanib Standards
- Nintedanib Impurity 158 (CAS 1023942-14-4)
- Nintedanib Impurity 9 (CAS 1038972-16-5)
- Nintedanib Impurity 156 (CAS 1040320-04-4)
- Nintedanib Impurity 19 (CAS 1125-88-8)
- Nintedanib Impurity 6 (CAS 1139453-98-7)
- Nintedanib Impurity N24 (CAS 1139455-52-9)
- Nintedanib Impurity N10 (CAS 1139457-10-5)
- Nintedanib Impurity N8 (CAS 1139458-48-2)
Recommended Standards
- Fosfomycin Impurity 68 (CAS 65102-51-4 (free base))
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- Fudosteine Impurity 33 (CAS CATO-C4X-144733)
- 4-Hydrazino-N-(3-methylphenyl)-4-oxobutanamide (CAS 443864-47-9)
- N1,N4-Bis[4-(trifluoromethoxy)phenyl]piperazine-1,4-dicarbothioamide (CAS 1020252-33-8)
- 2-Amino-3-(5-bromo-2-chlorophenyl)propanoic acid (CAS 1270324-45-2)
- 1-(4-(1H-Benzo[d]imidazol-2-yl)piperidin-1-yl)-3-(5-phenylfuran-2-yl)propan-1-one (CAS 1030202-35-7)
- 2-(Thiophen-2-yl)-N-((1-(p-tolyl)-1H-tetrazol-5-yl)methyl)acetamide (CAS 921166-04-3)
- 1-(3-Fluoro-5-(pentafluoro-l6-sulfanyl)phenyl)ethan-1-one (CAS 1240257-57-1)
- (His32,Leu34)-Neuropeptide Y (32-36) (CAS 168916-68-5)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com