1-(3-Nitrophenyl)piperazine CAS 54054-85-2
| CAS No. | 54054-85-2 |
| Molecular Formula | C10H13N3O2 |
| Molecular Weight | 207.23 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-(3-Nitrophenyl)piperazine.
1-(3-Nitrophenyl)piperazine (CAS 54054-85-2) is a high-purity analytical reference standard with the molecular formula C10H13N3O2 and a molecular weight of 207.23 g/mol.
The molecular framework of 1-(3-Nitrophenyl)piperazine (C10H13N3O2) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H13N3O2 |
| Molecular Weight | 207.23 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1972 |
| Nitrogen Atoms | 3 |
Related Nitrophenyl Standards
- 3-Methyl-4-(2-nitrophenyl)butan-2-one (CAS 1178221-04-9)
- (S)-2-(3-Nitrophenyl)piperazine (CAS 1212802-67-9)
- 3-Methyl-1-(3-nitrophenyl)butan-1-one (CAS 1267956-72-8)
- 2-(4-Nitrophenyl)piperazine (CAS 137684-53-8)
- 3-Methyl-1-(3-nitrophenyl)butan-2-one (CAS 1402614-81-6)
- 3-Methyl-3-(4-nitrophenyl)butan-2-one (CAS 15582-94-2)
- 1-(2-nitrophenyl)piperazine (CAS 59084-06-9)
- 1-(4-Nitrophenyl)pentan-1-one (CAS 22857-30-3)
Recommended Standards
- 1-(pyrimidin-2-yl)piperidine-4-carboxylic acid (CAS 303144-44-7)
- 1-(4-Nitrophenyl)pyrrolidin-3-amine (CAS 218944-30-0)
- 1-(2-isocyanatoethyl)-3,5-dimethoxybenzene (CAS 480439-01-8)
- 1-(6-Amino-5,6,7,8-tetrahydroquinazolin-2-yl)urea (CAS 929973-35-3)
- 3-Amino-3-(4-(trifluoromethyl)phenyl)acrylonitrile (CAS 71682-89-8)
- 2,6-Dichloro-4-(hydroxymethyl)phenol (CAS 22002-17-1)
- 1-(5-Chloro-2-methoxyphenyl)butan-2-ol (CAS 1247891-16-2)
- 2-(4-Ethylphenyl)acetyl chloride (CAS 52629-43-3)
- 4-(5-Chlorothiazolo[5,4-d]pyrimidin-7-yl)morpholine (CAS 41975-14-8)
- 11-(Perfluoro-n-hexyl)undecanol (CAS 134052-01-0)
- 6-Hydroxy-7-nitro-2,3-dihydro-1H-inden-1-one (CAS 85515-22-6)
- 6-(4-Fluoro-2-methylphenyl)pyridin-2-amine (CAS 882014-54-2)
- Doxorubicin Impurity 8 (CAS 20982-41-6)
- Semaglutide impurity 201 (CAS CATO-C4X-2226201)
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