Doxorubicin Impurity 8 CAS 20982-41-6
| CAS No. | 20982-41-6 |
| Molecular Formula | C21H14O7 |
| Molecular Weight | 378.33 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Doxorubicin Impurity 8 (CAS 20982-41-6, C21H14O7) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Doxorubicin Impurity 8 (C21H14O7) is characterized by a flavonoid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H14O7 |
| Molecular Weight | 378.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
Related Doxorubicin Standards
- Doxorubicin Impurity 7 (CAS 105612-58-6)
- Doxorubicin Impurity 14 (CAS CATO-C4X-203314)
- Doxorubicin Impurity 39 (Mixture of Diastereomers) (CAS 210837-87-9)
- Doxorubicin Impurity 6 (CAS 32384-98-8)
- Doxorubicin Impurity 12 (CAS CATO-C4X-203312)
- Doxorubicin Impurity 6 (CAS CATO-C4X-20336)
- Doxorubicin Impurity 5 (CAS 1159977-23-7)
- Doxorubicin Impurity 24 (CAS CATO-C4X-203324)
Recommended Standards
- Talazoparib Impurity 1 (CAS CATO-C4X-33731)
- Bosutinib Impurity 8 (CAS 2095306-22-0)
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- Latamoxef Impurity 5 (CAS CATO-C4X-17985)
- Verapamil Hydrochloride EP Impurity E (CAS 93-03-8)
- Ticagrelor Impurity 92 (CAS 88756-83-6)
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- Methyl (s)-3-(3-fluorophenyl)-3-hydroxypropanoate (CAS 1454691-23-6)
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- (11bS)-N-((S)-1-(2-(diphenylphosphanyl)phenyl)ethyl)-N-methyldinaphtho[2,1-d:1',2'-f][1,3,2]dioxaphosphepin-4-amine (CAS 913265-33-5)
- Ethyl (1-methyl-1H-1,2,3-triazol-4-yl)carbamate (CAS 99848-29-0)
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- Benzyl 2-(2,6-dioxo-4-(thiophen-2-yl)piperidin-1-yl)acetate (CAS 1421584-52-2)
- Hexapeptide-1 (CAS CATO-CPTD788821)
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