2-Chloro-N-(3-chloro-4-fluorophenyl)nicotinamide CAS 543721-72-8
| CAS No. | 543721-72-8 |
| Molecular Formula | C12H7Cl2FN2O |
| Molecular Weight | 285.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
2-Chloro-N-(3-chloro-4-fluorophenyl)nicotinamide (CAS 543721-72-8), molecular formula C12H7Cl2FN2O and molecular weight 285.10 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-Chloro-N-(3-chloro-4-fluorophenyl)nicotinamide (C12H7Cl2FN2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO manufactures 2-Chloro-N-(3-chloro-4-fluorophenyl)nicotinamide under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H7Cl2FN2O |
| Molecular Weight | 285.10 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 2-[2-chloro-4-(chlorosulfonyl)phenoxy]acetic acid (CAS 1017055-32-1)
- 5-Chloro-N-(5-chloropyridin-2-yl)-2-fluorobenzamide (CAS 1100018-31-2)
- 5-Chloro-4-(chlorosulfonyl)-2-methoxybenzoic acid (CAS 1375472-16-4)
- 2-Chloro-N-(2-chloropyridin-3-yl)-4-fluorobenzamide (CAS 648427-36-5)
- 4-Chloro-5-(chlorosulfonyl)-2-methoxybenzoic acid (CAS 57479-73-9)
- Ethyl 5-chloro-1-(4-chlorophenyl)-1H-pyrazole-4-carboxylate (CAS 110821-36-8)
- 5-Chloro-1-(3-chloro-4-methylphenyl)-3-methyl-1h-pyrazole-4-carboxylic acid (CAS 1152574-46-3)
- Ethyl 5-chloro-1-(2-chlorophenyl)-1H-pyrazole-4-carboxylate (CAS 121716-34-5)
Recommended Standards
- 4-(3,4-Dichlorophenyl)-2-fluorobenzoic acid (CAS 926235-03-2)
- 2,6-dichloro-5-fluoro-N-phenylnicotinamide (CAS 680217-79-2)
- 2-(3,4-Dichlorophenyl)-5-fluorobenzoic acid (CAS 926224-35-3)
- 5-[(4-Bromo-1H-pyrazol-1-yl)methyl]-2-furohydrazide (CAS 402729-65-1)
- 2-Chloro-n-cyclopropyl-n-[(4-methoxyphenyl)methyl]acetamide (CAS 874594-87-3)
- N-Cyclohexyl-4-methylpyridin-2-amine (CAS 522628-76-8)
- (5,6-Dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-8-yl)methanol (CAS 87664-90-2)
- 2-(Piperidin-3-yloxy)-N-((tetrahydrofuran-2-yl)methyl)acetamide (CAS 1706447-38-2)
- 3-methylisoquinoline (CAS 1125-80-0)
- (2-methoxyethyl)(2,2,2-trifluoroethyl)amine hydrochloride (CAS 1221726-25-5)
- (1S,2S)-2-(dimethylamino)cyclohexan-1-ol (CAS 29783-01-5)
- Omarigliptin Impurity 9 (CAS 1280210-79-8)
- [2-(Chloromethyl)-5-Fluorophenyl]Methanol (CAS 313232-91-6)
- Semaglutide Impurity 177 (CAS CATO-C4X-2226177)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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