2,6-dichloro-5-fluoro-N-phenylnicotinamide CAS 680217-79-2

Description

The occurrence of 2,6-dichloro-5-fluoro-N-phenylnicotinamide is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

2,6-dichloro-5-fluoro-N-phenylnicotinamide (CAS 680217-79-2) is a high-purity analytical reference standard with the molecular formula C12H7Cl2FN2O and a molecular weight of 285.10 g/mol.

The molecular framework of 2,6-dichloro-5-fluoro-N-phenylnicotinamide (C12H7Cl2FN2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 2,6-dichloro-5-fluoro-N-phenylnicotinamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

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