Ethyl 4-amino-3-iodo-5-nitrobenzoate CAS 543740-76-7
| CAS No. | 543740-76-7 |
| Molecular Formula | C9H9IN2O4 |
| Molecular Weight | 336.08 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Ethyl 4-amino-3-iodo-5-nitrobenzoate (CAS 543740-76-7), molecular formula C9H9IN2O4 and molecular weight 336.08 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Ethyl 4-amino-3-iodo-5-nitrobenzoate (C9H9IN2O4) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, iodine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H9IN2O4 |
| Molecular Weight | 336.08 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 2 |
Related Ethyl Standards
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- (R)-2-(4-Amino-6-bromo-2,2-dimethylchroman-4-yl)-2,2-difluoroethanol (CAS 1415108-83-6)
- 3-Amino-2-((2,4-dichlorophenoxy)methyl)quinazolin-4(3H)-one (CAS 648859-11-4)
- Methyl 5-amino-2-((4-bromobenzyl)oxy)benzoate (CAS 1555098-90-2)
- (2-Amino-4,5-dimethoxyphenyl)(4-bromophenyl)methanone (CAS 477742-51-1)
- 2'-Amino-6-bromo-4',5'-dimethoxy-[1,1'-biphenyl]-2-carbaldehyde (CAS 477742-53-3)
- Methyl 2-[4-(2-amino-4-bromophenoxy)phenyl]acetate (CAS 946743-71-1)
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Recommended Standards
- 2-Iodo-N-methoxy-N-methyl-4-nitrobenzamide (CAS 774238-67-4)
- 1,4-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene (CAS 99770-93-1)
- 1,3,5-Trifluoro-2,4,6-tris(trifluoromethyl)benzene (CAS 793-92-0)
- 1-(4-(2,4-Dichlorobenzoyl)-1H-pyrrol-2-yl)-2,2,2-trifluoroethan-1-one (CAS 241146-72-5)
- 4-Bromo-1-(2,2,2-trifluoroethyl)-1H-pyrazol-3-amine (CAS 1006471-06-2)
- 3-Borono-5-bromo-2-fluorobenzoic acid (CAS 957120-63-7)
- 1,2,3,4-Tetrahydrocyclopenta[b]indole-2-carboxylic acid (CAS 35418-49-6)
- Eldecalcitol Impurity 43 (CAS CATO-C4X-214043)
- Relugolix Impurity 3 (CAS CATO-C4X-24293)
- 2-(Adamantan-2-ylidene)acetic acid (CAS 25220-07-9)
- 2-(((3-Bromothiophen-2-yl)methyl)amino)-N,N-dimethylacetamide (CAS 1250529-88-4)
- 6-Chloro-[2,3'-bipyridine]-5-carboxylic acid (CAS 65049-28-7)
- (2E)-3-(5-ethylfuran-2-yl)prop-2-enoic acid (CAS 77741-65-2)
- Neuropeptide EI (human, mouse, rat) (CAS 125934-45-4)
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