3-Methoxythiophene-2-carbonyl chloride CAS 54450-14-5
| CAS No. | 54450-14-5 |
| Molecular Formula | C6H5ClO2S |
| Molecular Weight | 176.62 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 3-Methoxythiophene-2-carbonyl chloride (CAS 54450-14-5), a certified reference material (molecular formula C6H5ClO2S, MW 176.62 g/mol) for analytical method development and quality control.
The molecular framework of 3-Methoxythiophene-2-carbonyl chloride (C6H5ClO2S) is characterized by a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-Methoxythiophene-2-carbonyl chloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H5ClO2S |
| Molecular Weight | 176.62 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1972 |
| Halogen Content | Cl-containing |
| Sulfur Atoms | 1 |
Related Methoxythiophene Standards
- 4-Methoxythiophene-3-carbonyl chloride (CAS 224649-28-9)
- 4-Methoxythiophene-3-carbohydrazide (CAS 125605-39-2)
- Methyl 3-methoxythiophene-2-carboxylate (CAS 62353-75-7)
- methyl 4-methoxythiophene-2-carboxylate (CAS 5118-05-8)
- Methyl 4-methoxythiophene-3-carboxylate (CAS 65369-22-4)
- Ethyl 4-methoxythiophene-3-carboxylate (CAS 20946-39-8)
- 3-Methoxythiophene-2-sulfonamide (CAS 1394041-28-1)
- 5-Methoxythiophene-2-sulfonamide (CAS 140646-38-4)
Recommended Standards
- 3-Chlorothiophene-2-carbohydrazide (CAS 478483-31-7)
- 4-Chloro-2-(methylsulfinyl)pyrimidine (CAS 97229-10-2)
- 3-Chloro-4-methylthiophene-2-carboxylic acid (CAS 229342-86-3)
- 2-Chloro-N-(1,3-thiazol-2-yl)acetamide (CAS 5448-49-7)
- (3,4-Difluorophenyl)(4-(pyrrolidin-1-ylmethyl)phenyl)methanone (CAS 898776-91-5)
- 2-Chloro-3,4-difluoro-1-methylbenzene (CAS 1026525-97-2)
- 4-(Allylamino)-2-((2-chlorobenzyl)thio)-6-phenylpyrimidine-5-carbonitrile (CAS 303985-72-0)
- Methyl 2-(furan-2-carboxamido)thiophene-3-carboxylate (CAS 271778-22-4)
- Empagliflozin impurity 254 (CAS CATO-C4X-1065254)
- 4,6,7-Trichloro-1-methyl-3-oxo-1,3-dihydroisobenzofuran-5-carbonitrile (CAS 194923-81-4)
- 2-[(4-chlorophenyl)sulfonyl]-5-oxo-5-phenylpentanamide 303150-90-5 KS-00002Z3K (CAS 303150-90-5)
- (3-Bromo-5-methoxy-4-((3-methylbenzyl)oxy)phenyl)methanol (CAS 752991-26-7)
- Pioglitazone EP Impurity G (CAS 952187-99-4)
- Semaglutide Impurity 246 (CAS CATO-C4X-2226246)
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