Lorazepam EP Impurity D CAS 54699-91-1
| CAS No. | 54699-91-1 |
| Molecular Formula | C15H10Cl2N2O2 |
| Molecular Weight | 321.16 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Lorazepam EP Impurity D (CAS 54699-91-1, C15H10Cl2N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Lorazepam EP Impurity D (C15H10Cl2N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 11.0, corresponding to approximately 11 ring(s) or double-bond equivalent(s). With a molecular weight of 321.16 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H10Cl2N2O2 |
| Molecular Weight | 321.16 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1972 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Lorazepam Standards
Recommended Standards
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- 4-Bromo-2-(4-methoxybenzyloxy)-benzaldehyde (CAS 1099608-97-5)
- N-Benzyl 5-borono-2-methoxybenzenesulfonamide (CAS 874219-51-9)
- Phenethyl 5-bromo-2-hydroxybenzoate (CAS 1131587-60-4)
- Lubiprostone Impurity 40 (CAS CATO-C4X-113640)
- Dotinurad Impurity 244 (CAS CATO-C4X-2494244)
- Finerenone Impurity 191 (CAS CATO-C4X-2880191)
- Pemafibrate Impurity 84 (CAS CATO-C4X-290384)
- 2-[(2,4-Dimethylphenyl)sulfanyl]-N-[3-fluoro-4-(4-phenylpiperazin-1-yl)phenyl]acetamide (CAS 478260-50-3)
- (3aS,6R,6aR)-6-(iodomethyl)-4-methoxy-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxole (CAS 1093683-24-9)
- (E)-2-(3-((3-bromophenyl)amino)-1-(dimethylamino)allylidene)malononitrile (CAS 339102-35-1)
- Ivabradine Impurity 44 (CAS 866783-13-3)
- Etoposide EP Impurity A (CAS 124151-67-3)
- Tau Peptide (298-312) trifluoroacetate salt (CAS 330456-47-8)
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