Ivabradine Impurity 44 CAS 866783-13-3
| CAS No. | 866783-13-3 |
| Molecular Formula | C12H17NO2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Ivabradine Impurity 44 (CAS 866783-13-3, C12H17NO2HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Ivabradine Impurity 44 (C12H17NO2HCl) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Ivabradine Impurity 44 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H17NO2 HCl |
| Molecular Weight | 243.73 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Ivabradine Standards
- Ivabradine Impurity 25 HCl (CAS 1132079-01-6)
- Ivabradine impurity 90 (CAS 1132667-04-9)
- Ivabradine Impurity 9 (CAS 1204612-29-2)
- Ivabradine Impurity 28 (CAS 1206230-28-5)
- Ivabradine-d3 Hydrochloride (CAS 1217809-61-4)
- Ivabradine impurity 86 (CAS 1220993-44-1)
- Ivabradine Impurity 20 (CAS 1235547-06-4)
- Ivabradine Impurity 21 (CAS 1235547-07-5)
Recommended Standards
- Ivermectin EP Impurity I(Mixture of Diastereomers) (CAS 1135339-49-9)
- Otilonium Bromide Impurity 12 (CAS CATO-C4X-194412)
- Oxazepam impurity 1 (CAS CATO-C4X-30901)
- *(Z)-11-Tetradecen-1-yl-acetate Solution, 100 mg/L, 1 ml (CAS 20711-10-8)
- 1-(4-Bromophenyl)-3-(tert-butyl)-1H-pyrazol-5-amine hydrochloride (CAS 903566-95-0)
- (3Z)-3-(3,4-Dimethoxyphenyl)-4-[(4-phenoxyphenyl)amino]but-3-en-2-one (CAS 339017-40-2)
- Dimethindene (CAS 5636-83-9)
- 1-Amino-2-(5-methylfuran-2-yl)propan-2-ol (CAS 1344687-75-7)
- 2,3-Dibromo-4-(difluoromethyl)pyridine (CAS 1374659-29-6)
- Des-[Ser]8-Liraglutide (CAS CATO-C4X-199233)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com