N,N'-(1,2-phenylene)diisonicotinamide CAS 548480-36-0
| CAS No. | 548480-36-0 |
| Molecular Formula | C18H14N4O2 |
| Molecular Weight | 318.33 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies N,N'-(1,2-phenylene)diisonicotinamide (CAS 548480-36-0), a certified reference material (molecular formula C18H14N4O2, MW 318.33 g/mol) for analytical method development and quality control.
The molecular framework of N,N'-(1,2-phenylene)diisonicotinamide (C18H14N4O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C18H14N4O2 |
| Molecular Weight | 318.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1984 |
| Nitrogen Atoms | 4 |
Recommended Standards
- N-(3-Cyano-5-phenyl-2-furyl)-3-methoxybenzenecarboxamide (CAS 478033-45-3)
- N,N'-(1,2-phenylene)dinicotinamide (CAS 39642-80-3)
- N-(3-(1H-Benzo[d]imidazol-2-yl)phenyl)-3-methylisoxazole-5-carboxamide (CAS 946286-57-3)
- N,N'-(1,2-Phenylene)dipicolinamide (CAS 67455-94-1)
- 2-Chloro-5-(trifluoromethoxy)benzimidazole (CAS 886465-16-3)
- 4-Chloro-1-(3-chlorobenzyl)-1h-pyrazol-3-amine (CAS 1341733-48-9)
- 2-(Cyclopentylamino)-1-(4-fluorophenyl)-2-oxoethyl isoxazole-5-carboxylate (CAS 606102-36-7)
- Tert-butyl 1,3,6-trimethyl-1h,4h,5h,6h,7h-pyrazolo[3,4-b]pyrazine-4-carboxylate (CAS 1375473-79-2)
- Betacarotene EP Impurity C (CAS CATO-C4X-28153)
- 5-Ethyl-1H-indole-2-carboxaldehyde (CAS 58518-54-0)
- (4-((3-Chlorophenyl)sulfonyl)phenyl)methanamine (CAS 1362754-96-8)
- Fmoc-α-allyl-DL-Gly-OH (CAS 221884-63-5)
- 6-(Piperidin-3-yl)nicotinamide dihydrochloride (CAS 1361112-64-2)
- [Nva12]-Tirzepatide (CAS CATO-C4X-324042)
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